Absolutely stunning tour de force work here combining two of my favorite topics - advanced imaging and the actin cytoskeleton ๐ ๐ ๐
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๐ช๐ต๐ฎ๐ ๐ถ๐ณ ๐ฐ๐ฒ๐น๐น๐ ๐ต๐ฎ๐๐ฒ ๐๐ป๐ฑ๐ถ๐๐ฐ๐ผ๐๐ฒ๐ฟ๐ฒ๐ฑ ๐บ๐ฒ๐๐ต๐ผ๐ฑ๐ ๐ณ๐ผ๐ฟ ๐บ๐ฎ๐ป๐ฎ๐ด๐ถ๐ป๐ด ๐๐ต๐ฒ๐ถ๐ฟ ๐ถ๐ป๐๐ฒ๐ฟ๐ป๐ฎ๐น ๐น๐ผ๐ด๐ถ๐๐๐ถ๐ฐ๐?I'm pleased to share that our collaborative study, led by the brilliant Catherine G Galbraith and James Galbraith, along with Brian English and myself, has been published in ๐ก๐ฎ๐๐๐ฟ๐ฒ ๐๐ผ๐บ๐บ๐๐ป๐ถ๐ฐ๐ฎ๐๐ถ๐ผ๐ป๐! This project has truly been a ๐น๐ฎ๐ฏ๐ผ๐ฟ ๐ผ๐ณ ๐น๐ผ๐๐ฒ, featuring ๐น๐ฎ๐๐ฒ-๐ป๐ถ๐ด๐ต๐ ๐ถ๐ฃ๐๐๐ ๐ถ๐บ๐ฎ๐ด๐ถ๐ป๐ด ๐๐ฒ๐๐๐ถ๐ผ๐ป๐, ๐ถ๐ป๐ป๐ผ๐๐ฎ๐๐ถ๐๐ฒ ๐ฑ๐๐ฒ ๐๐ฒ๐๐๐ถ๐ป๐ด, and extensive use of the ๐๐ฎ๐ป๐ฒ๐น๐ถ๐ฎ ๐ฐ๐น๐๐๐๐ฒ๐ฟ'๐ ๐ฐ๐ผ๐บ๐ฝ๐๐๐ถ๐ป๐ด ๐ฟ๐ฒ๐๐ผ๐๐ฟ๐ฐ๐ฒ๐.Through extensive experiments at the Howard Hughes Medical Institute (HHMI)'s Janelia Research Campus, Oregon Health & Science University, and the Marine Biological Laboratory, utilizing techniques like ๐๐๐ฆ, ๐ง๐๐ฅ๐, ๐๐ฅ๐๐ฃ, ๐ฆ๐ฃ๐ง, ๐ฆ๐๐ , and ๐ถ๐ฃ๐๐๐ , we've uncovered ๐ถ๐ป๐๐ฟ๐ถ๐ด๐๐ถ๐ป๐ด ๐ถ๐ป๐๐ถ๐ด๐ต๐๐ ๐ถ๐ป๐๐ผ ๐ฐ๐ฒ๐น๐น๐๐น๐ฎ๐ฟ ๐ฏ๐ฒ๐ต๐ฎ๐๐ถ๐ผ๐ฟ. Our findings reveal that ๐ฎ๐ฐ๐๐ถ๐ป ๐ฐ๐๐๐ผ๐๐ธ๐ฒ๐น๐ฒ๐๐ฎ๐น ๐๐ฟ๐ฒ๐ฎ๐ฑ๐บ๐ถ๐น๐น๐ถ๐ป๐ด forms a ๐ฝ๐ฎ๐ฟ๐๐ถ๐ฎ๐น๐น๐ ๐ฝ๐ฒ๐ฟ๐บ๐ฒ๐ฎ๐ฏ๐น๐ฒ ๐ฎ๐ฐ๐๐ถ๐ป-๐บ๐๐ผ๐๐ถ๐ป ๐ฏ๐ฎ๐ฟ๐ฟ๐ถ๐ฒ๐ฟ,ย where ๐ฐ๐ผ๐ป๐๐ฟ๐ฎ๐ฐ๐๐ถ๐ผ๐ป ๐ฎ๐ ๐๐ต๐ฒ ๐ฏ๐ฎ๐ฟ๐ฟ๐ถ๐ฒ๐ฟ ๐ด๐ฒ๐ป๐ฒ๐ฟ๐ฎ๐๐ฒ๐ ๐ฎ ๐ฑ๐ถ๐ฟ๐ฒ๐ฐ๐๐ฒ๐ฑ ๐ณ๐น๐๐ถ๐ฑ ๐ณ๐น๐ผ๐ that propels proteins toward the cell edge. This creates what we describe as a "๐ฝ๐๐ฒ๐๐ฑ๐ผ-๐ผ๐ฟ๐ด๐ฎ๐ป๐ฒ๐น๐น๐ฒ" โ a ๐ณ๐๐ป๐ฐ๐๐ถ๐ผ๐ป๐ฎ๐น ๐ฐ๐ผ๐บ๐ฝ๐ฎ๐ฟ๐๐บ๐ฒ๐ป๐ ๐๐ถ๐๐ต๐ผ๐๐ ๐ฎ ๐๐๐ฟ๐ฟ๐ผ๐๐ป๐ฑ๐ถ๐ป๐ด ๐บ๐ฒ๐บ๐ฏ๐ฟ๐ฎ๐ป๐ฒ that nonetheless shapes how the cell behaves, coordinating protein distribution through ๐ฎ๐ฑ๐๐ฒ๐ฐ๐๐ถ๐ผ๐ป ๐ฎ๐ป๐ฑ ๐ฑ๐ถ๐ณ๐ณ๐๐๐ถ๐ผ๐ป.This research challenges existing views onย ๐ถ๐ป๐๐ฟ๐ฎ๐ฐ๐ฒ๐น๐น๐๐น๐ฎ๐ฟ ๐๐ฟ๐ฎ๐ป๐๐ฝ๐ผ๐ฟ๐๐ฎ๐๐ถ๐ผ๐ป, suggesting that cells have ๐๐ป๐ถ๐พ๐๐ฒ ๐ผ๐ฟ๐ด๐ฎ๐ป๐ถ๐๐ฎ๐๐ถ๐ผ๐ป๐ฎ๐น ๐๐๐ฟ๐ฎ๐๐ฒ๐ด๐ถ๐ฒ๐ ๐ณ๐ผ๐ฟ ๐บ๐ฎ๐ป๐ฎ๐ด๐ถ๐ป๐ด ๐ฝ๐ฟ๐ผ๐๐ฒ๐ถ๐ป ๐ฑ๐ถ๐๐๐ฟ๐ถ๐ฏ๐๐๐ถ๐ผ๐ป. It provides a ๐ป๐ฒ๐ ๐ฝ๐ฒ๐ฟ๐๐ฝ๐ฒ๐ฐ๐๐ถ๐๐ฒ on how cellular architecture supports ๐ฟ๐ฎ๐ฝ๐ถ๐ฑ ๐ฎ๐ฑ๐ฎ๐ฝ๐๐ฎ๐๐ถ๐ผ๐ป ๐๐ผ ๐ฒ๐ป๐๐ถ๐ฟ๐ผ๐ป๐บ๐ฒ๐ป๐๐ฎ๐น ๐ฐ๐ต๐ฎ๐ป๐ด๐ฒ๐.This study underscores the ๐ฐ๐ฟ๐๐ฐ๐ถ๐ฎ๐น ๐ถ๐บ๐ฝ๐ฎ๐ฐ๐ ๐ผ๐ณ ๐บ๐ผ๐ฑ๐ฒ๐ฟ๐ป ๐ผ๐ฝ๐๐ถ๐ฐ๐ฎ๐น ๐๐ฒ๐ฐ๐ต๐ป๐ผ๐น๐ผ๐ด๐ in enhancing our comprehension of biology, resonating with ๐ฆ๐๐ฑ๐ป๐ฒ๐ ๐๐ฟ๐ฒ๐ป๐ป๐ฒ๐ฟ'๐ ๐ถ๐ป๐๐ถ๐ด๐ต๐: "๐ฃ๐ฟ๐ผ๐ด๐ฟ๐ฒ๐๐ ๐ถ๐ป ๐๐ฐ๐ถ๐ฒ๐ป๐ฐ๐ฒ ๐ฑ๐ฒ๐ฝ๐ฒ๐ป๐ฑ๐ ๐ผ๐ป ๐ป๐ฒ๐ ๐๐ฒ๐ฐ๐ต๐ป๐ถ๐พ๐๐ฒ๐, ๐ป๐ฒ๐ ๐ฑ๐ถ๐๐ฐ๐ผ๐๐ฒ๐ฟ๐ถ๐ฒ๐ ๐ฎ๐ป๐ฑ ๐ป๐ฒ๐ ๐ถ๐ฑ๐ฒ๐ฎ๐, ๐ฝ๐ฟ๐ผ๐ฏ๐ฎ๐ฏ๐น๐ ๐ถ๐ป ๐๐ต๐ฎ๐ ๐ผ๐ฟ๐ฑ๐ฒ๐ฟ."