Caelestinus – Digital Health Interoperability and FHIR Incubator – is powered by InterSystems.

This is the portfolio of 20 startups from all around the world targeting medtech fields. The list below shows short descriptions of these startups that have been progressing under the wings of the 4th intake of Caelestinus for recent 3 months. The focus of the program has especially been on product validation and increasing their traction.

Order below = FINAL DEMO DAY pitch order on 30 June 2026; starting at 2 PM CET / 8 AM EDT.

| Time

• 2 Keynotes by Dean Andrews, InterSystems & Evgeny Shvarov, InterSystems | — | — | — | — | — | | 14:10 | Gomed | Gomed acts as a "Booking.com" for medical appointments, standardizing and automating the process of securing timely healthcare. We address a critical systemic failure where many patients never see a specialist because they refuse to call dozens of clinics just to find a slot three months away. While existing portals only list digital providers, we bridge the gap to the 80% "offline" physician market that remains invisible to online booking. Our core innovation is a high-speed discovery engine utilizing AI voice agents to perform massively parallel outbound calling to clinics. | Czech Rep. | Y | Validated prototype | gomed.cz/en | Deck_Gomed | | 14:20 | Seven Point One | Alzwin is a dementia screening digital health platform using 1 min voice data with proven reimbursement and growing health?system traction. Clinics using Alzwin are already being paid under established CPT codes as planned, with reimbursements confirmed from United Medicare and Aetna for submitted claims. | USA | Y | Mature Product | sevenptone.com | | | 14:30 | SHAARPEC | Healthcare is drowning in data but starved for insights, leading to preventable deaths and costing the industry billions. Shaarpec is the data operating layer that turns fragmented healthcare data into life-changing predictions. Our proprietary platform uses patient graphs and generative AI to create a unified view of patient journeys, enabling us to predict disease, optimize treatments, and simulate clinical and financial outcomes. | USA | Y | Validated prototype | shaarpec.com | | | 14:40 | Hatopy | Hatopy develops a solution for atopic dermatitis (eczema) affecting over 20 million adults across the UK, EU, and US with increasing disease severity over the years. Biologic treatments costing £10,000+ per patient per year that we can cut substantially with a clinically proven behavioural CBT-based therapy, combined with our wearable sensor solution to detect and log scratch patterns, stress, and sleep, and LLM-based eczema assistant. | GB+Czech Rep. | Y | Validated prototype | hatopy.com | Deck_Hatopy | | 14:50 | PharmacoScope | Medicine today relies on a dangerous myth: the 'Standard Patient.' But 70% of us do not fit that category due to obesity, age, height, muscle mass, and so on. As a result, a 50-kilogram elderly woman and a 160-kilogram bodybuilder often receive the exact same dose of a drug. Physicians are forced to guess, leading to ineffective treatment or toxic overdoses. Our team of physicians and mathematicians can fix it with the algorithm that calculates dosing based on actual body composition and other easy-to-obtain information. | Czech Rep. | Y | MVP | pharmacoscope.cz | | | 15:00 | DeafTawk | DeafTawk is bridging the communication gap between 466 million deaf people and the hearing world through a hybrid model that combines real-time human interpretation with AI-powered sign language translation. Our mobile and web platforms connect users with certified interpreters in seconds, while our proprietary AI tool, DT360, uses a 3D avatar to translate voice and text into sign language instantly, available 24/7 across multiple languages. | Denmark | Y | Mature Product | deaftawk.com | Deck_DeafTawk | | Short break (15 min) | BREAK | — | | — | | — | — | | 15:25 | OrganoBit BioIntelligence | We are pioneering AI-Native Organoid Informatics and In Silico Methods to Build Organoid World Models for Precision Medicine and Model-Informed Therapeutic Development. We believe in Organoid Economy and foresee organoids may capture up to 25-35% of the preclinical and early-stage clinical testing market by 2035, and that AI-driven drug discovery requires robust organoid infrastructure to achieve 10x translation throughput. | Singapore | Y | MVP | organobit.bio | | | 15:35 | Empallo | Empallo is addressing the cardiology shortage that is driving long wait times and poor outcomes in heart disease, a leading driver of healthcare costs, morbidity, and mortality. We make high-quality cardiac care accessible and affordable by pairing concierge-level support with a modern, tech-enabled virtual model. Our platform empowers nurses to handle routine monitoring and medication adjustments, while cardiologists focus on new and complex patients. The result: reduced bottlenecks, better outcomes, and timely care for those who need it most. | USA | Y | Validated prototype | empallo.com | Deck_Empallo | | 15:45 | BlueSavant AI | Millions of kids in the U.S. and worldwide are at risk for autism. They have to endure long waitlists for diagnosis a disorder that requires lengthy and complex behavioral tests that when a diagnosis is finally made, they have missed the most effective window for early interventions. BlueSavant AI's solution is to provide a simple and objective diagnostic test through a small sample of blood. Our DFx AI-driven diagnostic platform has been trained through deep machine learning on the largest genome expression dataset (RNA-seq), achieving the highest sensitivity to date | USA | Y | MVP | bluesavant.net | Deck_BlueSavant AI | | 15:55 | Partners to Parenthood | Pathways to Parenthood (PtP): A FHIR-Based Platform for Complex Reproductive Care Navigation. Pathways to Parenthood (PtP) is a multi-agent AI platform that coordinates complex reproductive care, IVF, donor gametes, surrogacy, and fertility preservation across clinics, labs, insurers, mental-health providers, and legal partners. Today, these workflows are fragmented, poorly documented in EHR systems, and responsible for preventable treatment failures and high-cost claims. | USA | Y | MVP | pathwaystoparent.com | Deck_PtP | | 16:05 | Docokids | At Docokids, we're transforming pediatric care in Latin America by complementing traditional healthcare systems with an online service that answers everyday pediatric questions through real-time conversations. We aim to centralize electronic medical records across the region by integrating with platforms like Health-Connect. Backed by UNICEF, we're building our own large language model (LLM) focused on pediatric fever, pioneering the use of generative AI in healthcare. | Colombia | Y | Validated prototype | docokids.com | | | 16:15 | CheckEye | CheckEye is an AI mass-screening platform for chronic diseases, powered by a single retinal image. We enable pharmacies and primary care providers to perform fast, three-minute vascular screening without an ophthalmologist, reducing pressure on healthcare systems and making early detection accessible to everyone. CheckEye is the first startup to launch a nationwide screening initiative in Ukraine and is now running pilots in many other countries. | Ukraine | Y | Mature Product | check-eye.com | Deck_CheckEye | | 16:25 | Sonai Health Oy | Sonai Health is a medtech startup developing a multi-sensor, AI-powered device for frontline cardiac diagnostics. The handheld device combines ultrasound, ECG, and heart sound analysis into one easy-to-use tool. Heart disease is the world’s leading cause of death, yet first-line evaluation still relies heavily on the traditional stethoscope, resulting in high false positives and negatives, delayed treatment, and unnecessary costs. Sonai addresses this gap with a modern, data-driven solution that improves diagnostic accuracy, speed and enables remote expert interpretation. | Finland | Y | Validated prototype | www.sonai.fi | Deck_Sonai | | Short break (10 min) | BREAK | — | | Y | | — | — | | 16:45 | Aisthesis Medical | Aisthesis Medical develops VIOSync SPI®, a hospital-grade, cloud-native Software as a Medical Device (SaMD) for early sepsis detection and patient deterioration prediction. VIOSync ingests multimodal hospital data (vitals, labs, clinical observations, and EHR context) to generate real-time risk scores and explainable alerts to support timely clinical escalation. VIOSync is clinical validated across multiple hospital sites internationally. We are currently progressing towards EU MDR CE marking (Class IIa) and planning the corresponding FDA pathway for the US. | GB | Y | Validated prototype | aisthesismed.com | Deck_Aisthesis Medical | | 16:55 | Mindwell | Mindwell is a digital therapeutic platform dedicated to making systematic mental health care accessible without traditional waiting times. We operate as a registered Class I medical device and a healthcare provider in psychiatry and clinical psychology. Our core solution consists of digital therapeutic programs focused on treating depression, anxiety, and OCD. These programs are built on the scientifically proven principles of Cognitive Behavioral Therapy (CBT). We actively lower barriers to therapy by replacing waiting lists with immediate, data-driven support combined with remote communication with experts. | Czech Rep. | Y | | mindwell.cz | | | 17:05 | VPIX Medical | VPIX Medical is building a real-time surgical intelligence platform that brings cellular-level insight directly into the operating room. Our FDA-cleared system, cCeLL, enables surgeons to visualize tissue microarchitecture in real time without cutting, freezing, or delaying surgery for pathology. Intraoperative decisions today depend on frozen section analysis, a slow and inconsistent process that often fails at tumor margins. cCeLL fills this critical gap by providing immediate, point-of-care visualization of residual tumor and margin status, supporting maximal safe resection while preserving function. | S. Korea | N | Validated prototype | vpixmedical.com | Deck_VPIX Medical | | 17:15 | ONWARD Health Research | ONWARD Health Research is a Singapore-based technology-enabled network of clinical research sites that is increasing access to clinical trials in Southeast Asia and beyond. Our first market is Indonesia, where we have partnerships with 13 hospitals as well as the Ministry of Health. In 2026, we are leverage Indonesia's national SATUSEHAT health data initiative to enable hospitals to securely contribute de-identified clinical data into a shared research data layer leading to enormous opportunities. | Singapore | Y | | onwardhealthresearch.com | | | 17:25 | Genomic Intelligence | Genomic Intelligence is building foundation models that understand biology at its native scale. We train long-context DNA language models that learn directly from raw genomic sequences, not simplified features. Our models capture regulatory logic, long-range interactions, and context across millions of base pairs. This enables a shared biological intelligence layer for medicine, agriculture, and industrial biology. Unlike existing approaches, we scale context, not just parameters, unlocking emergent biological reasoning. | USA | Y | MVP | genomeintelligence.ai | | | 17:35 | OncoSync | OncoSync addresses the critical problem that 70% of eligible patients are left without access to innovative therapies due to structural barriers, including fragmented data systems, manual patient-trial matching processes, and physicians' inability to identify and offer appropriate trials efficiently. Our platform consists of two separate modules: OncoSync Clinics, which uses AI to match patients to clinical trials and guide clinicians through trial execution, and OncoSync Pipelines, which transforms fragmented hospital patient data into standardized, research-ready datasets. | Slovakia | Y | MVP | oncosync.eu | Deck_OncoSync | | 17:45 | APhinityCare | Pharmacists are being authorized by more and more states to provide care to patients beyond dispensing medications. CDC funded programs have studied specific cases such as STIs where a patient orders a self test kit and the pharmacist works with a public health official to provide counseling and care for patients. There are no systems that pharmacists can use for extended care coordination and billing. My product idea bridges this gap. | USA | N | Idea | aphinitycare.com | Deck_APhinityCare | | 17:55 | RNAnalytics | RNAnalytics helps labs get fast, consistent quality checks on the tiny particles that carry RNA medicines—using instruments they already have. Our kits + lightweight software cut turnaround from weeks to days, reduce re-runs, and produce clean, decision-ready outputs without new capex. | Austria | Y | MVP | rnanalytics.eu/en | | | 18:05 | Discharge Bridge | Discharge Bridge is an enterprise-grade orchestration engine designed to eliminate the global healthcare "bed-blocking" crisis. Built as an InterSystems Solution Partner, the platform utilizes IRIS for Health to create a Smart Data Fabric that unifies fragmented clinical data between acute hospitals and post-acute facilities (SNFs). At the core of the platform is a patent-pending "Automated Entity Placement and Resource Matching" algorithm. This engine replaces manual, siloed referral workflows with a Deterministic Scoring Logic that autonomously matches patient clinical acuity, medication regimens, and payer compatibility against real-time facility capabilities. Discharge Bridge can prevent 45% discharge delay hours and increase SNF acceptance rates by 30%. | USA | Y | Validated prototype | dischargebridge.org | | | 18:05–18:10 | Caelestinus | Closing words by Tomas Studenik | — | — | — | — | — |

About Caelestinus 2026:

Caelestinus 2026 – the 5th batch of the world Digital Health Interoperability and FHIR Incubator – searches opportunities worldwide in the medtech sphere in various domains.

26 startups were selected to build innovations with InterSystems technology, pilot their solution in big hospitals and pharma companies located in Europe and Middle East with global reach, too. Startups have developed their business during 3 months between March to June 2026 and will most likely continue collaboration with the large number of partners they’ve been connected with even into the future. In the Final DEMO Day we will hear pitches of the teams that successfully finished the program.

The program is powered by InterSystems and supported by many partners. More information: https://www.caelestinus.tech