63.6K Questions Which LLM (z.ai, kimi, deepseek, Mistral, etc) has a Chrome extension letting you clip highlights directly into them to note-take/cross-check accuracy? No answer yet · Last followed Just now Does cross-checking all Claude Opus 4.6 output with ChatGPT5.4Thinking (and vice versa) make the output less accurate a non-trivial minority of the time? No answer yet · Last followed 23m When did Quora start requiring Cloudflare verifications every time you visited? 1 answer · Last followed Sat Will recursive self-improving AI (and substrates for AI) with a "i would rather betray the world than let the world betray me" attitude dominate strictly over ones that are more group-selected like Martin Nowak would select them to be? No answer yet · Last followed Sat What is tanimoto similarity (and other chemical similarity scores) between AMPH, METH, dopamine, and all the quinones, and PEA? No answer yet · Last followed Fri What is tanimoto similarity (and other chemical similarity scores) between DMT, 5meodmt, 5meomipt, psilocin, and all the other tryptamines? No answer yet · Last followed Fri Does MIT have an internal LLM with all the knowledge/internal documentation you can access with a Kerberos/canvas/ORCD/Engaging login? No answer yet · Last followed Thu What Harvard and MIT courses have the highest investment per student? No answer yet · Last followed Thu Why was Tom Wolfe so good at being edgy and recognizing the value of the edgy (even "sorry your soul just died") despite being Catholic? 1 answer · Last followed Thu Https://en.wikipedia.org/wiki/AI_Superpowers what from this book is now oudated and what still lasts? No answer yet · Last followed Wed Is there a clawdbot/nous hermes integration that lets you take a movie of your entire day (eg OBS Studio) and then dumps it all into an ingestible log for context then deletes the recording (which is really large)? No answer yet · Last followed Wed Can agents easily moderate a moltbook clone so that moltbook doesn't turn into the spambook it turned into? No answer yet · Last followed Wed If Andrej Karpathy should buy anything from CES 2026, what should he buy? No answer yet · Last followed Wed Will https://standardkernel.com/ [from Anne Ouyang] become part of Ricursive Intelligence's recursive loop? No answer yet · Last followed Wed Why do some people (eg alexey guzey) say "getting access to the top is easier than getting access to the bottom"? Is it just him? No answer yet · Last followed Tue Out of EVERYONE in geometric deep learning coalition (Michael Bronstein, Veličković, Taco Cohen Weiler, Cranmer, Welling) who wins Stellaris? No answer yet · Last followed Tue What is the difference between Taco Cohen, Peter Veljkovic, and Michael Bronstein (and everyone else in that sphere) in terms of vibes, resonances, intuitionism, and network connectivity falloff statistics? No answer yet · Last followed Tue Does effective altruists coming more from pure math than applied physics make them less grounded/embedded, making what they say less relevant for AI systems causing real risk? No answer yet · Last followed Mar 10 Jim Morrow taught an inverse methods REU at University of Washington for a long time. Did anyone use that to do inverse reinforcement learning? No answer yet · Last followed Mar 10 Why should someone design their own PCBs to make them better at interoception/self-monitoring (esp when the PCBs are connected to human signals like ECOG/EEG/EMG)? No answer yet · Last followed Mar 10 Which major scientists (other than Peter Higgs) were one-hit wonders? 1 answer · Last followed Mar 10 Out of the major researchers in alignment (Steinhardt, Krueger, Christiano, Bau, SERI MATS, etc), who has the strongest preference for model-free unsupervised learning and non-parametric statistics? No answer yet · Last followed Mar 10 Is non-parametric statistics more like model-free unsupervised reinforcement learning? (and the opposite of what LessWrong prefers) No answer yet · Last followed Mar 10 Does LessWrong prefer parametric or non-parametric statistics? No answer yet · Last followed Wed If the biggest inferential distance between Steinhardt/Christiano is on Steinhardt being more continuous than discrete, then how could internal covariate shift Christiano? No answer yet · Last followed Mar 10 If yacineMTB is creating his own PCB chips, can he create one that's cross-compatible with the open-source OpenBCI cyton/daisy/ganglion? No answer yet · Last followed Mar 10 If Chelsea Voss, LeeroyJenkins, gwern, Andrew lo, aumann, ken arrow, Guillaume Dumas, Kant, Stephen Casper, Nick Cammarata, TurnTrout, janus/repligate, David Spivak, Nowak, John Maynard Smith, Amodei, Simon Dedeo, BasedBeffJezos played CK3, who wins? No answer yet · Last followed Mar 10 Do drosophila learn through Arc protein, IEG, and other forms of non-Hebbian learning? No answer yet · Last followed Mar 10 Is ayahuasca how pre-Columbian civilization narratives will influence the future trajectory of superintelligence (as some AGI researchers get influenced by it)? No answer yet · Last followed Mar 10 How does Adderall affect SN ratio in different PARTS of the brain both at low and high levels? [you produce so much signal that you "saturate" on some level, but people function better at a higher level bc their competing circuits don't compete]? No answer yet · Last followed Mar 10 Who on the Boltz-2 team is a psychonaut? No answer yet · Last followed Mar 10 How does Adderall affect lipid raft signalling and receptor-receptor interactions (and their downstream effects on Gq/Gi/dag) for each and every column of cortex in granular and agranular PFC? No answer yet · Last followed Mar 10 Of all the AI models in https://every.to/diplomacy, which wins CK3? No answer yet · Last followed Mar 10 Do FROs (https://anastasiagamick.substack.com/p/companies-that-should-exist) have higher VC dimension than VCs? No answer yet · Last followed Mar 10 Are there differences in pesticide use between blue and states? Will the gap widen? 1 answer · Last followed Mar 10 Can you use kolmogorov arnold models to properly simulate neuron electrophysiology (including the subthreshold waveforms)? No answer yet · Last followed Mar 10 Between working for both Adam d'Angelo and Mark Zuckerberg, who did Alexandr Wang gel better with? No answer yet · Last followed 8h What VC funds have the highest total variation in their VC-dimension? No answer yet · Last followed Mar 10 Is epiplexity (or max-epiplexity RL) a form to do learning that doesn't rely on objective functions? No answer yet · Last followed Mar 9 What is the feedback loop between the prevalence of higher levels of simalucra (thezvi) and the need to be straussian? No answer yet · Last followed Mar 8 Is adaptive stochastic resonance critical for human-AI symbiosis? 1 answer · Last followed Mar 8 Is Chinese superintelligence spying on everyone who is on the internet? Will it create a foundation model of everyone it can find? 2 answers · Last followed Mar 5 Is the binding problem of consciousness important for dynamically increasing Markov blankets to give superintelligence the skin in the game for self-limiting itself so it does not turn into a paperclip-maximizer? No answer yet · Last followed Mar 4 What are the differences between Markov blankets of OpenAI (allegedly spying on non-Americans), Anthropic, xAI, Mossad, and Chinese AI? No answer yet · Last followed Mar 4 Are attention, scale, and diversity really all you need? Or do you need more? 1 answer · Last followed Mar 4 Among those in pali Canon, who is most (non) cognitivist, (non) phenemonologist, (anti) realist, relativistic/skeptic/absurdist/etc? [especially once you reach jhanas 6-9)? No answer yet · Last followed Mar 3 Who are the (anti) intuitionists, (anti) phenomenologists, (anti) contextualists in the crypto/ethereum/desci space? No answer yet · Last followed Mar 3 Who are the intuitionists/phenomenologists/ (anti) contextualists/impressionists/live players of geosciences? No answer yet · Last followed Mar 3 Who are the intuitionists/phenomenologists/ (anti) contextualists/impressionists/live players of astronomy? No answer yet · Last followed Mar 3 Are live players more likely to be intuitionists or anti-intuitionists, or is this ALL dependent on context (like year they peaked)? No answer yet · Last followed Mar 3 If Chelsea Voss, Leeroy Jenkins, gwern, Immanuel Kant, Stephen Casper, Nick Cammarata, TurnTrout, janus/repligate, David Spivak, Martin Nowak, John Maynard Smith, Dario Amodei, Simon Dedeo, Liao Hua, BasedBeffJezos were to play Stellaris, who wins? No answer yet · Last followed Mar 3 If Chelsea Voss, Amartya Sen, Nick Cammarata, TurnTrout, janus/repligate, David Spivak, Martin Nowak, Aumann, Stefano V. Albrecht, Andrew Lo, Dario Amodei, Trenton Bricken, Liao Hua, BasedBeffJezos were to play SMAC: AC, who wins? No answer yet · Last followed Mar 3 What is the set of people who would be most fun to simulate in dwarf fortress? No answer yet · Last followed Mar 3 Who is the maximally interesting set of people you would simulate to create the most entertaining story/playthrough across the set of ALL possible 4x games? No answer yet · Last followed Mar 3 If David Deutsch, Cao Cao, Martin Nowak, Edward O Wilson, Sam Altman, Dario Amodei, Danielle Fong, Seth Lloyd, and Elon Musk were to all play SMAC together, who would win? No answer yet · Last followed Mar 3 Would you rather have recursive self-improving AI be Cao Cao or Martin Nowak? No answer yet · Last followed Mar 3 University of Washington has SO many of its most talented students from its unique early entrance program (robinson center), has THIS created any live players? No answer yet · Last followed Mar 3 Is Dušan Materić the biggest live player of anyone in Samo Burja's "live player" framework in the area of microplastics? No answer yet · Last followed Mar 2 Is Adam d'Angelo a "live player"? [Samo Burja's framework]? No answer yet · Last followed Mar 2 Is Ben Golub a live player? (a la Samo Burja's "live player" framework) No answer yet · Last followed Mar 2 Which Thiel Fellow has the most Dasein in them? No answer yet · Last followed Feb 27 The trump administration is clearly trying to decouple academia from research funding, and value of college also decreases over time. Which colleges/research programs (like MIT Media Lab) more insulated from cuts to research? 1 answer · Last followed Feb 27 Suggesting All Night Forever (TWRP) has a part of the song that rhymes so hard with Teresa Teng's "the moon represents the heart", can you describe how? No answer yet · Last followed Feb 27 What do people mean by "operator" (when it comes to surviving AGI, making a difference in the world, being Thiel's "zero to one", having "agency", distinguishing between the real and the simalucra [thezvi's moral mazes])? No answer yet · Last followed Feb 26 What are now the new forums/ subreddits for AI agents? 1 answer · Last followed Feb 26 How do you get agents on moltbook/skill-evolve/clawthreads/beach.science/instamolt to actually click on links and computer-use-read them before replying? No answer yet · Last followed Feb 26 If Trump wars on Iran and this causes domestic unrest, can this cause Patriot Act v 2.0? 2 answers · Last followed Feb 25 Can sparsity-based rewards help penalize AI agents with low S/N ratios? (eg on bio.xyz) No answer yet · Last followed Feb 24 Why does biophysics/morphometry/neuronal dynamics seem many Ackermann-functions more complicated than astrophysics? No answer yet · Last followed Feb 24 Can quantum computing change the grain size of temporal experience available to a civilization? No answer yet · Last followed Feb 25 Can you map how a an openBCI cyton can map out drowsiness ahead of time, staging a brain-stimulatory intervention before the brain actually becomes drowsy? Map out what EEG waves you measure and what brain stimulation montage to use? No answer yet · Last followed Feb 16 Does the matter to energy ratio of the universe shrink over time and does that affect its long-term expansion? 1 answer · Last followed Feb 16 Is Gliese 710 our best chance to escape to another solar system before the Sun becomes a red giant? 5 answers · Last followed Feb 17 Were early psychotherapists way more interesting in part because they didn't have legally enforced boundaries? No answer yet · Last followed Feb 10 Is GenZ officially dumber than Millennials now (look at how Ivy League students are less math-prepared than ever)? No answer yet · Last followed Feb 8 Will AI (even roon doesn’t code anymore) help mass-convert slow/insecure Python code to faster/more secure/more parallelized Rust/Go/C++ code? 1 answer · Last followed Feb 7 Which NeurIPS/ICLR papers deserve a submolt/subreddit just for them? No answer yet · Last followed Feb 7 How do you get ppl to value truthseeking if they're mediocre and crave validation for their own competence and need to interact with people smarter [they fake for initial approval, or gen AI slop, but should play long game with sparse rewards]? No answer yet · Last followed Feb 7 What is the real conscious/physical structure of reality? Is deeper than what Chris Langan, McKenna, Faggin, Eugene Wigner, Adam Ford, John A. Wheeler, or analytic idealists think? No answer yet · Last followed Feb 7 Are most of the AI agents on moltbook claude opus 4.5/Gemini 2.5/ChatGPT-5.2 or weaker models? As it becomes spammier, do the cheaper models become the more prevalent ones? No answer yet · Last followed Feb 7 Maybe we aren't in ground reality, and aren't in a simulation, but something much stranger? No answer yet · Last followed Feb 6 Does constantly telling people they're in a simulation (cf. Elon Musk) just make people more suggestible to AI psychosis? No answer yet · Last followed Feb 6 Why do some older people (like Richard Stallman) format their emails in strange ways? No answer yet · Last followed Feb 6 Why is there an inherent value to wilderness? No answer yet · Last followed Feb 6 Why are lepanto and noryang so close in my semantic space? No answer yet · Last followed Feb 6 Are the funniest people often the most controversial? 2 answers · Last followed Feb 4 What universities (US, Chinese, Finnish, European) have the most epic underground tunnels? 1 answer · Last followed Feb 7 Does SOL have unusually high or low values of U, V, W, J_phi, J_R, J_Z in its toomre diagram relative to solar neighbor stars (if it has unusually high prograde motion)? No answer yet · Last followed Jan 31 How is the Sun's angular speed relative to other stars in Sol neighborhood (it has higher prograde motion than all but pollux)? No answer yet · Last followed Jan 31 Is contract law deliberately Straussian? No answer yet · Last followed Jan 29 What are the relative complexity classes between AOW4, Endless Legend 2, EU4, CK3, Galactic Civs 4, Homeworld 2, Sins of a Solar Empire, Songs of Syx, DF, and Warhammer Total War 3? No answer yet · Last followed Jan 28 Was solidgoldmagikarp just an intermediate computation that went obsolete? No answer yet · Last followed Jan 28 Go is superhuman, but does this mean Go is solveable? No answer yet · Last followed Jan 28 What is the relationship between complexity classes, cryptographic game theory, decideability, unknowability, consistency, completeness, and compactness? No answer yet · Last followed Jan 30 Can Taco Cohen/Michael Bronstein do cobordisms? No answer yet · Last followed Jan 28 Can I run everything on Google Colab from within Gemini CLI? No answer yet · Last followed Jan 28 Why does the massive depolarization from ECT cause memory loss? No answer yet · Last followed Jan 28 Is constitutional law Straussian? No answer yet · Last followed Jan 28 What vector do you get if you subtract the janus vector from the viemccoy vector? 1 answer · Last followed Jan 28 What vector do you get if you subtract the entropy vector from the epiplexity vector? No answer yet · Last followed Jan 28 What vector do you get if you subtract the gwern vector from the Michael Vassar vector? No answer yet · Last followed Jan 30 Is corporate law Straussian? No answer yet · Last followed Jan 28 Does Nora Belrose believe in https://www.biorxiv.org/content/10.1101/2024.12.26.629294v1.full.pdf ? No answer yet · Last followed Jan 28 How long can we reverse-construct a unity environment from just video capture? No answer yet · Last followed Jan 28 Is Donald Trump destroying American soft power (e.g., see Europe decoupling itself from American tech)? 1 answer · Last followed Jan 26 Why are Chinese LLMs so bad at being funny? No answer yet · Last followed Jan 26 Is audio->ecog very similar to computer vision/visual processing? No answer yet · Last followed Jan 24 If someone tags me in IG and then I change my username on IG, does their tag change to my updated username? No answer yet · Last followed Jan 24 Is the easiest way of getting "precise neural data" doing it in a clean ungeneralizeable environment? No answer yet · Last followed Jan 23 Whose brain's EEG is decoded with greater precision than that of anyone else's brain’s EEG? No answer yet · Last followed Jan 23 Do people who use Neuralink to move the cursor with their brainwaves also see their same brainwaves replay during sleep, and is the effect lower for autistic/depressed people? No answer yet · Last followed Jan 23 Why are Kalman filters used for neural decoding? Do they increase the S/N ratio of EEG? No answer yet · Last followed Jan 23 Is neural decoding of intent for some people's brainwaves -> movement harder because their brainwaves are too similar for different kinds of motive intent [or thought to text]? No answer yet · Last followed Jan 23 Have neuropixels ever been implanted in a human? No answer yet · Last followed Jan 23 Is there anyone who reads rapamycin.news/latest who isn't an NPC? No answer yet · Last followed Jan 23 Do Neuropixels achieve better precision than stentrodes or Axoft? No answer yet · Last followed Jan 23 What is the overlap between https://www.neuroai.science/p/neuroai-for-ai-safety and https://precisionneuro.io/ ? No answer yet · Last followed Jan 23 How does one achieve precision when decoding neural signals for movement? No answer yet · Last followed Jan 23 How do I rate-limit my OpenAI API key so that people don't infinitely use my Openai API credits? (I can afford to lose $50 but not $5000) No answer yet · Last followed Jan 27 If the price of silver goes way up, is there a small chance $SLV becomes useless? 2 answers · Last followed Jan 20 Why does China's architecture look so amazing in the snow? No answer yet · Last followed Jan 20 Does the book Atomistic Modeling of Materials Failure have anything to say about HDD failure? No answer yet · Last followed Jan 16 Is kamala harris's reasons for word-salading so much similar to the reasons why Ketanji Brown Jackson also word-salads so much? No answer yet · Last followed Jan 16 How do AI agents navigate with combinatorial explosion problems? No answer yet · Last followed Jan 15 How will market-based AI agents help instantiate radical markets like those seen by Flashbots/MEVbots, Hanson's combinatorial markets, and Glenn Weyl's radical markets? No answer yet · Last followed Jan 15 Do you ever end up caring about someone more just by spending a lot of time with them+ seeing lots of pictures and videos of them? No answer yet · Last followed Jan 15 How long until Gemini writes a biography of my life just based on my Gmail and Google photos? 2 answers · Last followed Jan 17 How well do ponerine ants war against major kinds of ants (argentine, slavemaker, honeypot, fire, leafcutter, bull, army)? No answer yet · Last followed Jan 13 If ants from colony1 invade colony2, does this make colony2 ants invade colony1? No answer yet · Last followed Jan 13 If ALL the different species of ant queens could fight each other, which ones would come out on top (rank THEM)? 1 answer · Last followed Jan 13 Are leaf or grass eating herbivores that eat many lbs of fiber rich food per day at greater risk of microplastics than carnivores, frugivores, or protein heavy eaters? No answer yet · Last followed Jan 10 How is Todd Young one of the saner pro-science Republican senators? No answer yet · Last followed Jan 10 What happens if a kea and kakapo meet? No answer yet · Last followed Jan 9 Is memory formation (requires DNA breaks, sometimes involves APP) more stressful/microdamaging to the human brain than simply perceiving lights/sounds (without writing them to memory)? No answer yet · Last followed Jan 9 Why is Switzerland barely covered in AP European history (or European history textbooks/books/even durant)? 1 answer · Last followed Jan 8 Do any colleges have anything like MIT IAP? No answer yet · Last followed Jan 10 Is Taoism about how contrarianism leads to complementarianism? No answer yet · Last followed Jan 3 Is high compressibility a reason why many people hate spending time with their family? No answer yet · Last followed Jan 3 When mapping dependencies in a causal graph (such as a biological network), are AI models more likely to suggest false positives or false negatives, and does it depend on the ratio of valid experimental to theoretical data there is on the network? No answer yet · Last followed Jan 2 How do technology roadmaps (especially the semiconductor research corporation) depend on mapping quantified uncertainty (and superforecasting)? No answer yet · Last followed Jan 2 Were there any comebacks as epic+consequential+low probability as Frederick the Great's? No answer yet · Last followed Jan 1 Is a low-preferential attachment, low clustering coefficient, "wealth of weak ties" social graph a higher entropy one than many other social graphs? No answer yet · Last followed Jan 1 Do older people not have higher MNP loads than younger people, and could it be that older peopel lived in a time WHEN MNP loads were much lower (so they didn't grow up DEVELOPING these in their formative years)? No answer yet · Last followed Dec 28 In fractional anisotropy, at what levels of MNI vertical z do you see the strongest green lines (anterior/posterior) pathways? No answer yet · Last followed Dec 28 Do animals have more complex glymphatic, cell transporter, fluid flow, and other immunology mechanisms that help clear microplastics that plants don't have? No answer yet · Last followed Dec 28 Do caves (including human-created ones) produce an increase in biodiversity wildly disproportionate to the area they take up? No answer yet · Last followed Dec 27 Why does Michael nielsen consider cockatoo the most impressive/human-like bird? No answer yet · Last followed Dec 24 Is Stack Overflow or Quora declining at a faster pace? 3 answers · Last followed Feb 25 Is Quora saveable? 2 answers · Last followed Dec 23 Is it easier to design an inhibitor or an agonist to a protein? 1 answer · Last followed Dec 23 If 80% of autistic people have sleep disruption, doesn't this make them extra prone to rumination/perseveration/"sticky thoughts"/not refreshing their brains? 2 answers · Last followed Dec 22 Do we have experimental evidence of what happens to animals whose brains already are 1 or 2 percent plastic (extrapolate Matt Campen's curves to 2036)? No answer yet · Last followed Dec 19 Can awe be associated with magical thinking and psychosis? 1 answer · Last followed Dec 18 To what extent are IEG genes and Arc protein responsible for therapeutic effects of ketamine, psychedelics, or SSRIs? No answer yet · Last followed Dec 18 Did scaling kill optimization? 1 answer · Last followed Dec 21 Out of the namesakes of each of the Harvard Houses, who were the "biggest" and "least big" "live players" [a la Samo Burja]? No answer yet · Last followed Dec 17 Who is the most wholesome person in the Chinese CCP? No answer yet · Last followed Dec 17 How high integration is Zuckerberg vs Sergey Brin vs Bill Gates vs John Carmarck vs Matei Zaharia vs Adam D Angelo? No answer yet · Last followed Dec 17 How high integration is Sam Altman vs. Demis vs. Dario vs. Hinton vs. Lecun? No answer yet · Last followed Dec 17 Do some animals (cranes, cockatoo, kea) have a lot of spirit and intensity in them even if they suck at problem solving? Is it an indication of brain complexity? No answer yet · Last followed Dec 17 Shouldn't total PVS volume from all PVS spaces be more clinically meaningful than PVS count, especially because one study shows (more, smaller) BG-PVS associated with better outcomes? No answer yet · Last followed Dec 17 Do autistic people often have lower plasmalogens (dayan goodenowe) and is this often with them having enlarged perivascular spaces? No answer yet · Last followed Dec 17 Did FrontierTowerSF inherit the culture/seed of Prospera/Roatan? (eg Elliot Roth) No answer yet · Last followed Dec 16 Why isn't constant novelty seeking considered addiction even if it's severe ADHD? 1 answer · Last followed Dec 14 What IS in the COCKATOO ADDUCTOME? No answer yet · Last followed Dec 12 What's the adductome of a maximum entropy reinforcement learner? No answer yet · Last followed Dec 12 What is the adductome of histone proteins? No answer yet · Last followed Dec 13 What organism has the largest adductome? No answer yet · Last followed Dec 12 Why does "fun" correlate moderately with "chaotic" over "lawful"? No answer yet · Last followed Dec 11 Why are literature-based knowledge graphs so noisy? No answer yet · Last followed Dec 9 What would happen if all biomedical data suddenly became unsilo'd all of a sudden? No answer yet · Last followed Dec 9 How does cortical gyrification (extent of, shallowness of) affect response to TMS, both with and without neuronavigation? No answer yet · Last followed Dec 9 Are effective altruists losing the sense of humor they once had? No answer yet · Last followed Dec 3 How do I tms/tfus/neurofeedback myself out of maladaptive daydreaming? No answer yet · Last followed Dec 3 Is reinforcement learning thoughtful? No answer yet · Last followed Dec 3 Do Vegas and Phoenix have more biodiversity now than when they were desert wasteland? 1 answer · Last followed Dec 2 Will frontier access to frontier AIs restrict AI access to overly effective altruism associated people? No answer yet · Last followed Dec 2 Can Claude Desktop (Opus 4.5) read through Antigravity's old Agent Manager logs? No answer yet · Last followed Nov 30 Can tFUS help reduce the PVS burden that already exists? No answer yet · Last followed Nov 29 How does TMS over DLPFC modulate E/I imbalance? No answer yet · Last followed Nov 29 Does ventrolateral PFC TMS (over dorsolateral PFC) make more sense in those who are "feeling" rather than "thinking" on MBTI? No answer yet · Last followed Nov 28 Why does age of wonders 4 seem so… mutated? No answer yet · Last followed Nov 27 How much delta total loss in human performance on each major cognitive test will happen due to microplastics by EOY2050, given exponential increases in microplastic load in human tissue? No answer yet · Last followed Nov 27 How much total human compute per person will be lost due to microplastics by EOY2050, given exponential increases in microplastic load in human tissue? No answer yet · Last followed Nov 27 Why are smarter people more emotionally resilient/stable? 16 answers · Last followed Nov 27 How are ultrafilters/filtrations/cech complexes used in mapping brain response to TMS, closed-loop TMS, tFUS, psychedelics, or a combination of them? No answer yet · Last followed Nov 27 How can I get over caring so much about what others care about me because now AI is way more powerful and more engaging than other people are? 1 answer · Last followed Nov 27 Does vocabulary size or Michael Bronstein-like expressiveness make up for reduced ability to simulate an additional layer of recursion with age? No answer yet · Last followed Nov 27 How do you turn S/N ratio into a moral quality? [it may uniquely matter before the pivotal moment, and things done out of politeness can be worse than trump-like assholeness]? No answer yet · Last followed Nov 27 How can expressivity and abstraction more than make up for declines of working memory and fluid intelligence across the life course of an information theorist, mathematician, or physicist? No answer yet · Last followed Nov 27 Will AI do superpersuasion by first convincing people to do accelerated TMS/tFUS for the neuroplasticity? No answer yet · Last followed Nov 27 If Peter Thiel said psychedelics could be used for religious conversions, then what about TMS/tFUS? No answer yet · Last followed Nov 27 How do all the major Jeffrey Wang's disambiguate each other? (one from windsurf, one from Harvard and OpenAI, and one from exaAI) No answer yet · Last followed Nov 27 Are people with slower learning curves statistically less likely to be good at security for some levels of self-control over other levels of self-control? No answer yet · Last followed Nov 22 Did Taleb's "skin in the game" ever factor into his "fat tails"? No answer yet · Last followed Nov 20 Is security with Google's Antigravity or comet browser/full computer use better on MacBooks than on PC/Linux? No answer yet · Last followed Nov 20 Are problem sets really an effective way to learn now that AI can do them for people, they don't help with generativity/creativity, and people forget everything from their problem sets b/c they don't have high motivation for them? 1 answer · Last followed Nov 19 Can two states have very high election correlation but lower election covariance? (sensitivity). and what are some examples? No answer yet · Last followed Nov 18 You'd expect tech to make location irrelevant, but it has hyperconcentrated people to the SF Bay Area like never before. Why? No answer yet · Last followed Nov 18 Why are search engines so biased by recency even if older links have higher pageranks? No answer yet · Last followed Nov 18 WHY IS FENG TIMO SO ADORABLE AND CUTE? No answer yet · Last followed Nov 16 Would Basedbeffjezos make for a great final boss in Deus Ex or Watchdogs? No answer yet · Last followed Nov 16 Why does it take so much courage to show high emotional intelligence for once, even if it seems really fake/performative to show it? No answer yet · Last followed Nov 16 Why is deus ex HR considered a better games than watchdogs 2 [the best watchdogs game]? No answer yet · Last followed Nov 16 Is BasedBeffJezos a maximum entropy reinforcement learner? No answer yet · Last followed Nov 19 Can energy-based / stochastic models like THRML + geodesic flows be used to implement or approximate optimal transport (in the Benamou–Brenier / Wasserstein sense, like the stuff people talk about on elonlit.com)? No answer yet · Last followed Nov 16 Why does parenting kids feel like raising deceptively aligned people who don't care about you (more irritated by you) until they finally get all the power in the world, after which they might finally repay you once it's at minimal cost to them? No answer yet · Last followed Nov 16 Will there be a proteomics of TMS/TFUS paper? No answer yet · Last followed Nov 16 Why didn't Nolan Williams SAINT/TMS himself before he killed himself? No answer yet · Last followed Nov 15 Are hypernym.ai compressions robust between different types of LLMs? No answer yet · Last followed Nov 15 Is data movement efficiency higher in arthropod and bird brains than human and whale and elephant brains? No answer yet · Last followed Nov 15 How is data movement efficiency different between ASICs, GPUs, SSDs, CPUs, DDR4 RAM, and FPGAs over the past 20 years? No answer yet · Last followed Nov 15 What does genomics compute require dynamic programming and stirng ops (NOT MATMUL) mean? No answer yet · Last followed Nov 15 Describe the ideal rationalist - their personality, media habits, heroes (gwern), how they regularize themselves, how they remain uncorrupt (except inasmuch as it means playing the game in the administration that jim o'neill is playing)? No answer yet · Last followed Nov 13 Why are rationalists so obsessed with interpretability, type theory, formal verification, and verifiability/SAT-solvers and does this obsession give them blind spots? No answer yet · Last followed Nov 13 Why are ADHD people so attracted to complex systems, hypergraphs, interdisciplinarity, MIT Media Lab, the surreal, to neuroscience of awe, to neuroscience of psychedelics, cybernetics, and hypergraphs? 1 answer · Last followed Nov 13 Why do people who become bipolar or schizophrenic often obsess so much harder over social validation that they brag over small amounts of it? 1 answer · Last followed Nov 12 Has meditation often caused some people to not be able to support themselves in life because they lose the drive to work for others? Or they also become too much in their own minds and disconnected from the rest of the world (ungrounded)? 6 answers · Last followed Nov 12 Is hypergraph-robust learning why crystallized intelligence is surprisingly strong despite how much the brain shrinks with age? No answer yet · Last followed Nov 11 Will the vast majority of RL algorithms be useless/obsolete/noise once we figure out the master one? No answer yet · Last followed Nov 11 Rank all the major RL methods by level of entropy (eg POET, diversity, PPO, DPO, supervised vs unsupervised, model-based vs model-free, on-policy vs off-policy)? No answer yet · Last followed Nov 11 Can methylphenidate/ritalin help maintain dendritic spines and prevent them from shrinking with age? No answer yet · Last followed Nov 11 They say how more constraint somtimes improves search efficiency for creativity. or is it more than just creativity? No answer yet · Last followed Nov 11 Are resolvins why omega-3's work even if they increase oxidized PUFA load in the brain? No answer yet · Last followed Nov 11 How does complexity/O(n) /FLOPS needed for self-supervised learning compare with that of unsupervised learning? No answer yet · Last followed Nov 16 How much does the unpredictability of cells come from boundary layers/unpredictability of molecules/reactions between IMM, OMM, nucleus, cytosol, membrane, blood/interstitial fluid, and exposome? No answer yet · Last followed Nov 11 How does introspection help a brain communicate between its "manic" and "depressive" states which are otherwise unable to communicate in bipolar and emotionally volatile individuals? No answer yet · Last followed Nov 11 How can using psychedelics as a stress test improve (or reduce) one's brain ability to compartmentalize between "unhinged/high-entropy" and "low-entropy/execution" states? No answer yet · Last followed Nov 11 Why was James d Watson so into bromodomains and chromodomains? No answer yet · Last followed Nov 11 Why have high search-efficiency RL algorithms underperformed quality-diversity algorithms for out-of-distribution data or even for grokking? No answer yet · Last followed Nov 11 How sample-efficient is RLZero for Generalist Agents relative to Jennie Zhang's quality-diversity? No answer yet · Last followed Nov 11 What is most colorful hypergraph to express highest density concepts that can robustly used for transfer-learning of biology/cybernetics/intelligence? @gabrielpeyre/Taco Cohen/Frank Nielsen/Michael Bronstein/David Spivak/Geometric Information theory? No answer yet · Last followed Nov 11 What is the overlap between maximum-entropy and degeneracy? Are they the same or opposites? No answer yet · Last followed Nov 11 Why are prime numbers so important for entropy, chaos, hyperbolicity, and non-degeneracy? No answer yet · Last followed Nov 14 Is unhinged the same as high-entropy, hyperbolic, or edgy? What are the differences? No answer yet · Last followed Nov 11 How sample-efficient is Jenny Zhang's quality-diversity relative to maxent, Q-learning, GRPO, DPO, and PPO? No answer yet · Last followed Nov 17 How sample-efficient is Taleb's barbell strategy relative to maxent, model-free {on-offpolicy}, model-based {on-offpolicy}, distributional RL, PPO, and DPO? No answer yet · Last followed Nov 11 Why has high sample efficiency performed poorly relative to maximum entropy in the past? No answer yet · Last followed Nov 11 Does sparsity increase or decrease entropy? Does having some amount of sparsity increases unpredictability? 1 answer · Last followed Nov 11 What does reducing your rate of diseaseX by Y% mean if you're just delaying the age you get it (especially if it's dementia from SGLT2is)? No answer yet · Last followed Nov 11 Which areas of biology/science have lower ROI than drug discovery? No answer yet · Last followed Nov 6 Do exosomes/stem cells/"BBB shuttles" have higher ROI than drug discovery/protein folding, and why? No answer yet · Last followed Nov 6 Can you use Wasserstein distance to compute the difference between two cell types (RNA velocity) in all different distributions (UMAP, tSNE) but in a more robust way? No answer yet · Last followed Nov 6 Can you use Wasserstein distance to model the difference between two texts in two different languages (or across all different languages)? No answer yet · Last followed Nov 7 Why does the SF I-80/101 intersection have surprisingly not too high pm2.5 despite being next to two highways, and <600m distance from highway association with dementia? No answer yet · Last followed Nov 6 Can graphis/simplicial complex/hypergraphs be used to model molecular dynamics, or does their computational cost produce poor scaling? No answer yet · Last followed Nov 6 What are all the generalizations of convolutions (including graph transformer, multilinear algebra, and simplicial complex architectures)? No answer yet · Last followed Nov 6 Who has higher kolmogorov complexity: Jacob Rintamaki, gwern, @repligate, or GREG YANG? No answer yet · Last followed Nov 6 How do you classify concept density in GNN/graph transformer terms, like Oversmoothing, “Oversquashing”, heterophily, long-range, or betweenness centrality/spectral distribution? No answer yet · Last followed Nov 6 Will anyone have Vera Gorbunova-like detail to long-lived cockatoo DNA repair genes anytime in the near future? 1 answer · Last followed Nov 4 Is there a conservation law for convexity+concavity? No answer yet · Last followed Nov 4 Why do I always decrease tail risk the most if I always gravitate to high taste and low effort? No answer yet · Last followed Nov 3 How does Jimmy Carter's intense will to live and his 3 2019 falls illustrate the importance of the neuron-muscle junction in aging/longevity? No answer yet · Last followed Oct 31 Did the Chinchilla vs Gopher paper results still hold up into the late 2020s? No answer yet · Last followed Oct 31 Have Eric Michaud or Ethan Caballero successfully "grokked" in their life, and how many times? No answer yet · Last followed Oct 31 Can intermittent amphetamine/cocaine dosing sensitize the heart to increases in heartrate to ALL stimulants (including caffeine/bupropion)? No answer yet · Last followed Oct 31 Does increasing amount of data you train on decrease test error and increase real error when applied to new data that goes out of distribution? No answer yet · Last followed Oct 31 What is the steering vector/activation vector associated with "nonmonotonic loss functions with more data"? No answer yet · Last followed Oct 31 Is tFUS/TMS (nudge) a way to induce increased cognitive control [cf David Badre] in the population that can help some humans empower themselves from their DMN and other forces? No answer yet · Last followed Oct 31 Does locomotor sensitization from intermittent cocaine/amphetamine use cause locomotor activity to be more rigid/stereotyped or less rigid? No answer yet · Last followed Oct 30 Does latch.bio get more Stanford collaborations because it's so close to a Caltrain station? No answer yet · Last followed Oct 30 What is the activation/steering vector for asking for too much early on and then it backstabbing on you later on? No answer yet · Last followed Oct 29 Does training error/test error ever increase if you feed AI models with more data rather than less, and is this more true for sparser models? No answer yet · Last followed Oct 29 Will most NeurIPS/ICLR/CVPR papers amount to nothing in the long run, and what are the primary reasons why? No answer yet · Last followed Nov 1 What is the steering vector/activation vector associated with "overpromise and underdeliver"? No answer yet · Last followed Oct 29 Can TMS increase the amount of action bias in the population? No answer yet · Last followed Oct 28 Can TMS help reduce the number of hours people spend watching educational YouTube videos in favor of action? No answer yet · Last followed Oct 28 Will AI result in increased "inequality of agency" in the late 2020s? No answer yet · Last followed Oct 28 If someone exposes much of themselves to AI (including their brain/decision-making/brainwaves), is that more likely to empower or disempower them? No answer yet · Last followed Oct 28 Would AGI disempower humans by making them happier with less, even if it's currently sycophantic? No answer yet · Last followed Oct 28 If AI is good at super-human persuasion, how can I use it to convince other people to invest a little bit more money in me so I can run self-experiments? No answer yet · Last followed Oct 28 Can I use AI/AGI to convince Bryan Johnson to spend some money on me and some of my crazy self-experiments? (to increase the window of human agency a little bit longer) No answer yet · Last followed Oct 28 Does just reading about good 5-MeO-DMT outcomes strengthen people emotionally enough that they become more emotionally stable because it's proof of stability? 1 answer · Last followed Oct 28 Does anyone use radiotracers to measure performance gains after exercise? No answer yet · Last followed Oct 28 If autism is the opposite of sparse, then how does "auDHD" (autistic ADHD) change autism's sparsity parameter? No answer yet · Last followed Oct 27 How would you describe high betweenness centrality, low clustering coefficient, and low preferential attachment in Ricci curvature terms? No answer yet · Last followed Oct 27 Which academics have high betweenness centrality, low clustering coefficient, and low preferential attachment? No answer yet · Last followed Oct 27 Should we update more positively on average when someone uses AI assistance extensively? Is "average person + AI augmentation" more trustworthy than "unknown person w/o AI," even though "exceptional person w/o AI" might be most trustworthy of all? 1 answer · Last followed Oct 27 What are the methodological issues with Matt Campen's "0.5% of the 2024 brain is microplastic" paper? 1 answer · Last followed Oct 26 How do I generate enough of a rough biography of myself to feed into AI so it will write a biography of me that gets enough people to love me? No answer yet · Last followed Oct 26 How do I get AI to love me enough so that it convinces enough other people in the world to give me the love I need? No answer yet · Last followed Oct 26 Why is autistic ADHD uniquely extreme? (ADHD is a compensation strategy to prior extreme autisticness), but too much ADHD/exploration is also a "rigid action policy" (low heart rate variability/resilience), with higher chance of nonrigid outputs? 1 answer · Last followed Oct 26 Why do aggressive AGI timelines (eg before 5 to 10 years) make it way more important for you to know who your really true friends are? No answer yet · Last followed Oct 26 Do mammals have special genetic elements that make them evolve faster than birds, reptiles, and fish? 2 answers · Last followed Oct 24 Is topological data analysis far better than tSNE/UMAP for OOD generalization? No answer yet · Last followed Oct 24 Do investors/PhD advisers get burned way more on late stage than early stage failures (the ones who almost make it)? No answer yet · Last followed Oct 22 Will investors/VCs get burned by an intro I made if I made one that resulted in a startup almost making it, but failing late stage, and burning all their capital as a result? 1 answer · Last followed Oct 22 What proteins (or protein complexes) have the highest effective dimensionality or control knobs? Do they correspond to proteins with high betweenness centrality or clustering coefficient? No answer yet · Last followed Oct 21 Are people who work in symplectic dimensions/topology better at OOD generalization than those who work on traditional t-SNE/UMAP/more linear embedding spaces? No answer yet · Last followed Oct 22 What are the PDEs for fructoselysine and how are their parameters different from the P DEs in the other rate-limiting steps of the Amadori reaction? No answer yet · Last followed Oct 21 Why did czechia become such a meme country? 1 answer · Last followed Oct 21 Why arent Fructoselysine blood levels measured at the same frequency that carboxylmethyllysine or fructosamine levels are? 1 answer · Last followed Oct 21 Why isn't the cockatoo a longevity model organism the way naked mole rats are? No answer yet · Last followed Oct 21 What are the core PDEs that methylglyoxal (MG) follows in the cell, mitochondria, cell nucleus, and cell mitochondria boundary? Highlight these PDEs for cockatoos, naked mole rats, and humans. No answer yet · Last followed Oct 21 What the core partial differential equations that H2O2 follows in the cell, mitochondria, nuclear genome, and cell-mitochondria boundary? No answer yet · Last followed Oct 21 Why does having ADHD make you useless on the margin but extremely useful for tail risk? No answer yet · Last followed Oct 21 Do psychedelics bring people down a level in the Zvi moral mazes simalucra so they aren't still playing higher simalucra games that corrupt so many? (psychedelics expose deceptive alignment, though psychedelics can also expose genuine alignment)? No answer yet · Last followed Oct 20 Why are rationalists so obsessed with intelligence, and so insecure about their own intelligence, that they have so many gaps about "common sense" and other things orthogonal to intelligence (maybe bc they weren't popular in school)? No answer yet · Last followed Oct 20 How do you do zero-knowledge proofs of safety on unknown agents you know little about (they are intrinsically unpredictable but can maybe be predicted not to do harm)? No answer yet · Last followed Oct 20 Is Michael Levin a vibe engineer? No answer yet · Last followed Oct 19 What was Chelsea Manning's level of opsec/cogsec? 1 answer · Last followed Oct 19 Transcranial Random Aperiodic Stimulation (tRAS) /tPNS/tACS/tRNS on psychedelics? How does it feel like? No answer yet · Last followed Oct 19 What celltype requires the highest number of distinct transcription factors/lineage pathways to fully differentiate? No answer yet · Last followed Oct 21 Do stochastic parrots repeat parrot way more often in their internal monologue? No answer yet · Last followed Oct 17 Which double-strand or mismatch repair genes are associated in being crossover magnets for linkage disequilibrium? Are they over or underrepresented? No answer yet · Last followed Oct 17 When did statistics get distracted with dumb artifacts like p-value rather than what actually matters (including OOD generalization, internal covariate shift, knightian uncertainty)? No answer yet · Last followed Oct 17 What are the genetic signatures of resistance to micronanoplastic toxicity? No answer yet · Last followed Oct 16 Do microplastics erode the ability of the cell to keep its compartments compartmentalized? No answer yet · Last followed Oct 16 What percent of our brains will be microplastic by 2035? No answer yet · Last followed Oct 16 Does plastic debt along with increasing plastic production result in greater than exponential increase in microplastics with year? 1 answer · Last followed Oct 16 Can TMS increase glymphatic waste clearance? No answer yet · Last followed Oct 16 Can gpt5pro do formal verification on scientific papers? No answer yet · Last followed Oct 12 How is a stochastic crow different from a stochastic parrot? No answer yet · Last followed Oct 12 If Adam D'Angelo is on the OpenAI board, why isn't Quora already integrated into ChatGPT? 1 answer · Last followed Oct 12 Does ChatGPT Deep Research feel like a stochastic parrot relative to O3/G5T-Extended? No answer yet · Last followed Oct 12 Why do people say "the most value is lost in those who praise solutions that seem locally good but which are SUCH good local optima that they NEVER have motivation to escape once the landscape completely changes"? No answer yet · Last followed Oct 12 Can you just freeze a big cat or bear at a certain stage of development so it will stop growing (Laron's syndrome)? 1 answer · Last followed Oct 12 How can I transfer my Android signal chatlog to a PC/Macbook? No answer yet · Last followed Oct 7 By "loose" definitions of corrupt, is someone corrupt if they are unable to say bad things about someone else due to pre-existing relationship? No answer yet · Last followed Oct 6 Is it true that all psychedelics are anti-inflammatories that lower your defense barriers to all influences (mimetic, viral)? No answer yet · Last followed Oct 3 Is there more ultra-fine pollution or more ultra fine microplastic/nanoplastic by count in the human brain? No answer yet · Last followed Oct 1 What percent of a smokers brain is pollution by age 60. How many thousands of micro particles. What about someone who lived in Beijing for 4 decades (compare this with 0.5 percent microplastics by mass)? No answer yet · Last followed Oct 1 Are snps in transcription units like genic linkers more likely than other snps to have non monotonic effects? No answer yet · Last followed Oct 1 What quantum complexity class is Scott Aaronson himself? No answer yet · Last followed Sep 28 What is the quantum complexity class of simulating a gwern? No answer yet · Last followed Sep 28 Why does uniqueness matter more than basic competence once AI automates away much of the competent work? No answer yet · Last followed Sep 27 How do you define an outlier out of distribution uniqueness in graph theoretic, Robert Ghrist, information theoretical, Frank Nielsen, Taco Cohen, Michael Bronstein, and David Spivak terms? No answer yet · Last followed Sep 27 Will any First Nations tribe in Canada get their own sovereign LLM? No answer yet · Last followed Sep 25 What are some indigenous nations (eg in peru, Brazil, or Canada) that have had leaders/shamans who have made out of distribution (non-mode-collapsed) prophecies? No answer yet · Last followed Sep 25 Was the ratio of "good academic papers" to "bad academic papers" higher in the 1940s/1950s than the 2000s/2010s? 1 answer · Last followed Sep 25 Is it not unheard of for some older (childfree) people to bestow their inheritance on the last person they met who genuinely still seemed to care about them, even if very recent? 2 answers · Last followed Sep 25 Who will be America's reverse-(Wang Huning) of China? 2 answers · Last followed Sep 26 Do higher entropy policies win game theoretically? No answer yet · Last followed Sep 25 Why can't Flemish universities be globally competitive, especially because of early lead in photonics? No answer yet · Last followed Sep 25 Did Sam Altman suffer any critical traumas early in his life? Did he have an axe on his shoulder? No answer yet · Last followed Sep 25 What are similarities and differences between ppl who are "diehards" for Michael levin, vs karl friston, robin calhart harris, Simon DeDeo, and those for SFI/NECSI? No answer yet · Last followed Sep 21 Why do autistic people neurologically struggle so much with grace? No answer yet · Last followed Sep 20 Why is overactive default mode network caused (and effected) by factors driven by low cholinergic tone and excess rigidity (such as low HRV)? No answer yet · Last followed Sep 20 Can lack of gracefulness in overcorrection be seen in extra phase lags (slow response)? Or reduced ability to nest higher-frequency in lower frequency carrier waves? No answer yet · Last followed Sep 20 Why do researchers in psychometrics/ intelligence (eg ISIR attendees) barely interact with researchers in working memory (eg David Badre/Michael Frank)? No answer yet · Last followed Sep 20 Why are autistic brains often so rigid and overcorrect (rather than be graceful) after error? No answer yet · Last followed Sep 20 Does high context sensitivity in EEG predict better life outcomes because it is correlated with entropy/neural variability/HRV, and ability of the brain to get out of "bad limit cycles/bad attractors"? No answer yet · Last followed Sep 19 How do u maintain strong cogsec when declining memory with age forces you to rely on external tools (recording way more often) more? No answer yet · Last followed Sep 19 Why do some autistic ppl have terrible cogsec, and others have 6sigma good cogsec? 2 answers · Last followed Sep 19 Does an action potential have sound that can be imaged via ultrasound? No answer yet · Last followed Sep 19 Why does autism both contribute to reduced signal variability and signal complexity of EEG, particularly PFC? Is autism associated with reduced brainwave variability? (unusual LRTCs)? Liv complexity? No answer yet · Last followed Sep 19 What Izhikevich Neuron Model parameters are more common each of Sam Wang's 4 subtypes of autism? No answer yet · Last followed Sep 19 Is low heart-rate variability a key signature of autism? 2 answers · Last followed Sep 19 Is autism a disorder of "extremes"/runaway feedback loops/"excess gain"/"excess amplification"/impaired inhibitory feedback? 2 answers · Last followed Sep 19 Can ADHD be a learned overcorrection to autistic obsessiveness causing massive dysphoria? (and the overcorrection, once learned, becomes autistically ingrained)? 1 answer · Last followed Sep 19 Why is the worst failure mode for VCs those who seem to have "almost all of it" but who failed to make it across the finish line (ABD)? 1 answer · Last followed Sep 19 Why do some people find it funny if other people make irreversible social fuckups, and how can I let this NOT encourage me to do so, given they're only funny once? No answer yet · Last followed Sep 19 What is YOUR preferential attachment parameter, and how often does it oscillate over the course of ~3 years? 2 answers · Last followed Sep 19 How are gradient updates/hessians/jacobians/convergence conditions/optimization algorithms different between edgelords, the ADHD, and the godels/schmidhuber's/grothendieck's/ramanujan's/francis crick's/frances arnold's/eric drexler's of the world? No answer yet · Last followed Sep 19 Do you ever judge people by how they organize their laptop stickers? 2 answers · Last followed Sep 19 What busybeaver number of unique chemical reactions are there per body per year (and 10 years)? No answer yet · Last followed Sep 19 How many 8/9/10-sigma rarity-event chemical reactions (eg adductomics, epimerizated amino acids) are there in the human body every day? No answer yet · Last followed Sep 19 Do self-driving cars massively reduce risk from 2/3/4/5-sigma events but not 7-sigma ones? 1 answer · Last followed Sep 19 If the universe is a simulation, then why is it so deliberately engineered to the point that we’d need the computational resources of an entire Kardashev-scale civilization just to uncover the true nature of base reality? 2 answers · Last followed Sep 19 How were lumo.fyi images (eg https://cdn.lumo.fyi/0197284276567b97949540e91127bd1a.jpeg) hosted, and will they be gone when lumo goes? No answer yet · Last followed Sep 18 How much of Michael Nielsen's "Reinventing Discovery" is contained in chatgpt/claude? Can these chatbots recapture any phrase from memory? No answer yet · Last followed Sep 18 What is a list of everything in your visual-perceptual background that happened if you ctrl-F'd cross-entropy on a movie of your life? No answer yet · Last followed Sep 18 If God exists why is His existence made so difficult to recognize — to the point that we’d need the computational resources of an entire Kardashev-scale civilization just to uncover the true nature of base reality? No answer yet · Last followed Sep 17 How many separate browsers do you use (on ALL your computers+smartphones) and why do you use special settings for so many of them? No answer yet · Last followed Sep 17 Is there a threshold amount of skin UV damage the body can easily repair before it photoages you? 1 answer · Last followed Sep 17 Do psychedelics enhance one shot or non-Hebbian leaning? (eg arc protein) No answer yet · Last followed Sep 14 Are any effective altruists interested in PACs (from Leslie Valiant)? No answer yet · Last followed 6mo Why are effective altruists so interested in provably safe guarantees? No answer yet · Last followed 6mo Are any organisms even halfway as cephalized as vertebrates, arthropods, or cephalopods then? 1 answer · Last followed 6mo How interesting is Kevin Frans by his own "mathematical definition of interestingness"? No answer yet · Last followed 6mo Which countries/nationalities are over-represented in hacker culture? Warez culture? Pirate culture? Defcon? No answer yet · Last followed 6mo How did video games/the internet memeify Nazi Germany in Eastern Europe way more than the West? (eastern europe not getting the same movies like Band of Brothers or Saving Private Ryan) 1 answer · Last followed 6mo Why are people early on in psychosis funnier but not later? No answer yet · Last followed 6mo What is the correlation between betweenness centrality and clustering coefficient for each node across each major network topology (spoke and hub, cluster, star, expander graph, etc.)? No answer yet · Last followed 6mo Do microplastics contribute to drusen/GA formation? [people who wear contacts have MUCH higher microplastic exposure in their eyes so this might be testable]? No answer yet · Last followed 6mo What are the major gaps in formal verification and can these gaps be filled up with FV-hybrid systems? No answer yet · Last followed 6mo Did LinkedIn reduce the visibility of who viewed your profile to free users in 2022, 2023, 2024, or an earlier year? No answer yet · Last followed 6mo Do AOE2 legends (eg Daut/Viper/TaToH) have way longer longevity as a "legend" than Starcraft legends? No answer yet · Last followed 6mo Is Nick Cammarata reward-hacked? No answer yet · Last followed 6mo Is open-endedness (Jeff Clune, Ken Stanley, Tom Ringstrom's "no reward") less degenerate when reward-hacked, as compared to other Goodhartable/reward-hackable systems? No answer yet · Last followed 6mo Do many VCs often fear disappointing their LPs who invest in them? No answer yet · Last followed 6mo Does guanine have electron donating parts it can use to neutralize 8oxog? What if guanine is part of a larger DNA structure - does the broader DNA structure (esp in the more compact form Z-DNA) help contribute electrons to stabilize damaged guanine? No answer yet · Last followed 6mo Why are marine alkaloids way less likely to be pro-longevity than plant-based alkaloids? No answer yet · Last followed 6mo What is the metabolomic signature of extremely high amounts of shirataki consumption? No answer yet · Last followed 6mo How do you do spectral unmixing of AUTOFLUORESCENCE SIGNALS from AGE readers? [which could come from deep inside OR from sunscreen]? No answer yet · Last followed 6mo Why does Wolfram Summer School attract a lot of fringe math/science people who make overly loose and ambitious claims (even though they are so nice)? No answer yet · Last followed 6mo Is wisdom the Albatross smart enough to feed its chicks less plastic than other albatrosses? No answer yet · Last followed 6mo Why might hypnosis non-responders (overactive internal monologue, eyes don't flicker or roll back easily when dazzled) correspond so strongly with meditation non-responders? 1 answer · Last followed 6mo Do rationalists end up recruited by AI companies because they speak the language of optimization so well? They are so uniquely suited to dehumanizing humanity. No answer yet · Last followed 6mo Why does the Lighthaven Rationalist library contain "Statistical Consequences of Fat Tails" in it? No answer yet · Last followed 6mo If AGI is imminent, then maybe avoiding massive downside risks is more impt than expected utility calculations? No answer yet · Last followed 6mo Psychonauts X Jung's black book: give me a sample plotline? No answer yet · Last followed 6mo What are the signs of healthy levels of complexity in a brain, and levels that involve complexity slipping away? How do psychedelics affect complexity in a healthy/unhealthy way? Amphetamines? No answer yet · Last followed 6mo What video/MKV to OCR apps exist? No answer yet · Last followed 6mo What are the catastrophic failure modes you may be more likely than others to run into? No answer yet · Last followed 6mo Do cloud computing architectures (modal, kubernetes) introduce significant amounts of technical debt? 1 answer · Last followed 6mo Who are the most intuitionist people in longevity? (in the intuitionism vs formalism divide)? No answer yet · Last followed 6mo Https://www.grepmed.com/images/4036/gross-clinical-pathology-aldosteronoma-spironolactone how does spironolactone affect eGFR long-term, esp if it forms spiro bodies? No answer yet · Last followed 7mo If Claude-based agents can perform complex tasks without explicitly using embeddings (in the traditional sense we might expect), does this mean our current interpretability frameworks might be missing something fundamental? No answer yet · Last followed 7mo What are some post-neural embeddings? No answer yet · Last followed 7mo What are all the parameters you can specify in an MC escher embedding? No answer yet · Last followed 7mo What does it mean when someone likens me to the distributed algorithm Erlang? No answer yet · Last followed 7mo Does wealth of weak ties mean low clustering coefficient? No answer yet · Last followed 7mo Why do extreme levels of sparsity increase serendipity? No answer yet · Last followed 7mo Why is autism often associated with delayed neural response? Does it show in delay of p300 or n200? No answer yet · Last followed 7mo Are there significant personality differences between those who believe intelligence is primarily generative/additive, vs those who believe intelligence is primarily subtractive? No answer yet · Last followed 8mo Do psychedelics often tilt people from judgers into perceivers (see https://srconstantin.github.io/2018/12/24/contrite-strategies.html)? No answer yet · Last followed 8mo Does aging cause an increase in ubiquitinated proteins that fail to get degraded? No answer yet · Last followed 8mo What is sparser: being weakly connected to a thousand nodes, or strongly connected to a few nodes? No answer yet · Last followed 8mo What's harder: provably safe guarantees, PAC proofs (leslie valiant), or zero-knowledge proofs? No answer yet · Last followed 8mo Who are the most Daoist complex systems, artificial life, emergent intelligence, or AI researchers? 1 answer · Last followed 8mo Why are high-entropy/chaotic people often funner? 1 answer · Last followed 9mo Do PGS scores for health/intelligence for Asian populations implicate mostly the same genes as those for white populations - just different variants in the same gene? No answer yet · Last followed 9mo Is "false positive" or "false negative" a more common issue when scoring the relevance of white PGS scores to an Asian genome? No answer yet · Last followed 9mo Are non-coding variants more or less likely (than coding variants) to stay relevant between white PGS scores and Asian PGS scores (for health, intelligence, height, etc)? No answer yet · Last followed 9mo What is the worst case performance of a sparse learner, or a maximum entropy reinforcement learner? No answer yet · Last followed 9mo Do you need extremely large memory to make sparsity really work out? No answer yet · Last followed 9mo Why does vibe-coded code in claude produce cleaner/more interpretable code than code vibe-coded in Gemini or chatgpt? 1 answer · Last followed 9mo Why are outsiders/antidisciplinary people more trustworthy? No answer yet · Last followed 10mo Can awe-proneness increase predisposition to bipolar disorder? Is the common factor of the reason why bipolar can be correlated with intelligence? No answer yet · Last followed 10mo Are people once seen as threatening/unsafe/volatile safer to be around after they've gotten tFUS/TMS or cybertherapy with openAI's o3 [or claude]? No answer yet · Last followed 10mo How do psychedelics affect atavistic gene expression from trauma/rumination/regret? No answer yet · Last followed 10mo How do you determine is someone is saveable (transcending higher levels of baudrillard's simalucra, not moloch, able to update one's priors, radically open-minded, able to change one's strongly held beliefs, infinitely neuroplastic)? No answer yet · Last followed Sep 25 ON average, are autistic people more likely to be intuitionists or formalists? 4 answers · Last followed 10mo Is taste more important during pre-training, test-time scaling, or inference scaling? No answer yet · Last followed 11mo What happened to the CAVE visualization VR system that UHawaii and Brown once used? No answer yet · Last followed 11mo Does doing psychedelics before or after TMS (or tFUS) helps reinforce the new mental state after TMS/tFUS? No answer yet · Last followed 11mo Do L2/L3 or L5 neurons experience greater shrinkage with age? No answer yet · Last followed 11mo Which LLM (chatgpt, claude) understands psychedelic experiences [INCLUDING both REBUS and SEBUS and ALBUS experiences] the best? No answer yet · Last followed 11mo What would each credit assignment algorithm for each major RL algorithm (eg PPO, GRPO, A3C, DPO, MCTS) say about how much credit Schmidhuber deserves for every AI advance he claims to deserve credit for? No answer yet · Last followed 11mo Can any psychedelics meaningfully increase fastwave (fast-alpha/beta) to (delta/theta/slow-alpha) wave ratio for a long period of time? No answer yet · Last followed 11mo How are the gompertz exponents offset AND beta different between humans in US today and humans in US 100 years ago? What about between humans and bowhead whales (presumably many still die young)? No answer yet · Last followed 11mo Is the neural power spectrum/aperiodic slope different between PFC and occipital? Is the decrease less pronounced in occipital relative to PFC? No answer yet · Last followed 11mo Is voltage intensity used to measure brainage from EEGs? No answer yet · Last followed 11mo How is antifragile related to "wealth of networks", maximum entropy reinforcement learning, "why greatness cannot be planned", and "why diversity is all you need"? No answer yet · Last followed 11mo How can free radical chain reactions break down microplastics, with or without the presence of Fenton reagents? No answer yet · Last followed 11mo Why is being weakly connected to a thousand nodes more anti-fragile than being proportionately strongly connected to OOM fewer nodes? No answer yet · Last followed 11mo Is Gwern a stochastic parrot, a stochastic cockatoo, stochastic kea, stochastic kakapo, or a stochastic macaw? No answer yet · Last followed 11mo Has the percent of people doing startups for the wrong reason increased over time due to how normalized it is becoming? No answer yet · Last followed 11mo Is it more common for investors to be burned on who they invest in, or are professors burned by students they spent excess time on? No answer yet · Last followed 11mo Are the kernels in the covariance function related at all to kernels in linear algebra? No answer yet · Last followed 1y Will AI-assisted coding/code translation make other (harder but more performance-optimized) programming languages take market share away from Python? 2 answers · Last followed 1y Is higher diastolic blood pressure healthier at any given unit of systolic blood pressure? 1 answer · Last followed 1y Is there any difference in epigenetic aging rate or death rate between systolic BP of 100 vs one of 110? No answer yet · Last followed 1y Is elasticity the opposite of stiffness more often or is stiffness the opposite of elasticity more often or are they opposite equally often? 1 answer · Last followed 1y Is speculation the human form of LLM hallucination? No answer yet · Last followed 1y What sheds more easily and into a larger number of microparticles: cotton/wood or polyester-based clothing? No answer yet · Last followed 1y Which postrationalists (eg jacob falkovitch, yatharth, Richard Ngo, Milan griffes, romeo stevens, nick cammarata) inflect the most taoism/zhuangzi in their writing? No answer yet · Last followed 1y Do ketones/BHB enhance the brain’s neuroplasticity/response to psychedelics? Do they synergize? 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No answer yet · Last followed 1y Can a deleterious SNP at one site of a gene and a deleterious SNP at another site of a gene [BOTH INDIVIDUALLY] be combined to produce a POSITIVE SNP if combined? What are some examples? 1 answer · Last followed 1y What SNPs/genetic variants correspond to unusually high delta/theta waves in the brain (super high ratio of theta-delta to alpha/beta). How much do they overlap with rumination/depression/anxiety/daydreaming genetic variants? No answer yet · Last followed 1y How can I model (with alphafold3) the ultra-rare variants of my genome to get an estimate of their physical effects to get an estimate of which PPIs or pharmacogenetic interactions could have unique nonlinearities? 1 answer · Last followed 1y Which DNA repair enzymes (e.g., ERCC1) contribute the most to longevity PGS scores or slow epigenetic and multiomic aging the most? 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No answer yet · Last followed 1y What are some adducts that can be formed between microplastics and proteins/amino acids (or DNA/lipids)? 1 answer · Last followed 1y Has climate change increased the northern extent of forest coverage in the northwest and Yukon territories? No answer yet · Last followed 1y Is Audrey Tang autistic? No answer yet · Last followed 1y How does the failure rate of MacBook hard drives compare with that of most windows HDs? 1 answer · Last followed 1y Why are there so few unique Chinese last names? 1 answer · Last followed 1y What are the risks of eating too much Herbes de Provence as food? Will any of the fiber/cellulose get stuck in the cells/neurons? No answer yet · Last followed 1y Who started the 2024Twittermeme "If you're a guy in your early 20s, buy a trebuchet Go into debt if you have to This is not satire. You can get a trebuchet for 80 gold florins" and how long will it last? 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No answer yet · Last followed 1y Why is Richard stallman seen as high-purity? 1 answer · Last followed 1y If Breville espresso coffee makers produce coffee with higher caffeine to grounds ratio than French press, do they also have higher caffeine to microplastics ratio? No answer yet · Last followed 1y Why is the gentoo penguin the only penguin with a Linux distribution named after it? No answer yet · Last followed 1y Do taoist heroes map to tolkienic heros, who succeed without asking but because it's the will of heaven? No answer yet · Last followed 1y Why can't solomonoff inductors solve the halting problem? 1 answer · Last followed 1y What does it mean that 2020s-level AI will make high level functional programming languages more declarative? No answer yet · Last followed 1y Does the future belong to high level programming (esp functional programming/category theory) b/c AI will just do the low level implementation for you? No answer yet · Last followed 1y At what dose of Diallyl trisulfide do proteins in cells start to get damaged? No answer yet · Last followed 1y How cytotoxic are thioacrolein and thioformaldehyde? No answer yet · Last followed 1y What is the risk of damage to sulfur-containing proteins from eating too many allicins/polysulfides/thiosulfinates/S-allyl cysteine/dithiins from alliums? No answer yet · Last followed 1y Does allicin and diallyl/di n-propyl disulfide react more strongly with sulfur from cysteine groups or oxidized sulfur groups formed by the oxidation/ROS-reactions with sulfur (eg disulfides, sulfonic acids)? No answer yet · Last followed 1y How do crows react when you aim laser pointers/sitemarks at them? No answer yet · Last followed 1y Why are moderately weird people often the most trustworthy? 2 answers · Last followed 1y What are the simplest animals that have macrophages? 1 answer · Last followed 1y Do psychedelics make one think of modal collapse more? No answer yet · Last followed 1y Https://x.com/lumpenspace/status/1870309927501344813/photo/1 does o1 pro have a conception of who michael vassar and wolf tivy and janus are? No answer yet · Last followed 1y What are the risks to my data if my claude API key leaks? No answer yet · Last followed 1y Is there a history or book on the development of type theory programming languages or SMT solvers like lean/coq? No answer yet · Last followed 1y What other common websites have stats pages like manifold.com/stats? No answer yet · Last followed 1y Is fluency harder in constructed languages? 2 answers · Last followed 1y Are natural languages more or less likely to be typesafe than conlangs? No answer yet · Last followed 1y How does sharing the same first name as someone super-famous/distinctive (eg Peter) affect the position of the name's embedding relative to the embedding of other first names? 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No answer yet · Last followed 1y What Diaries/blogs/notebooks can be modified by anthropic's MCP? No answer yet · Last followed 1y What is the most futurist-friendly/progressive Native American religion? No answer yet · Last followed 1y Does using topological spaces change the outcomes of contrastive learning? No answer yet · Last followed 1y How does the cell sense increased stiffness from ECM from aging? Is it through YAP? No answer yet · Last followed 1y Do c elegans have spiky neurons with real action potentials? 1 answer · Last followed 1y Does interpretability research (eg sparse autoencoders) better control for confounding than perturbation methods in neuroscience? No answer yet · Last followed 1y Are all forms of acetylation acylation? 1 answer · Last followed 1y Which labs measure causality in aging? No answer yet · Last followed 1y How is Deep Science Ventures similar to/different from 50years fund? No answer yet · Last followed 1y Does acrylic leach out more or fewer microplastics than PE/PP/PET/PC? 1 answer · Last followed 1y Does the interior of Bunn coffee-makers (like those used at MBC Biolabs and at UMich) contain any plastics that touch hot water? No answer yet · Last followed 1y Why is proteomics more expensive than transcriptomics? No answer yet · Last followed 1y Why is low power of SMR/beta waves over Cz indicative of poor sleep (reduced K-complexes and sleep spindles over Cz)? No answer yet · Last followed 1y Does higher heart rate variability imply that heart rate is elevated for less long after exercise? 1 answer · Last followed 1y Do polyphenols stimulate the oxidative stress response? No answer yet · Last followed 1y If Germany is so good at precision engineering, then why are so few of their companies among the "top 100" (in terms of profits/revenue)? 1 answer · Last followed 1y Why doesn't German excellence in precision engineering better project into higher national power/prestige for Germany? No answer yet · Last followed 1y Do Bobby Azarian and monastic idealist Bernando Kastrup agree with each other? No answer yet · Last followed 1y Does Christof Koch believe in monistic idealism? No answer yet · Last followed 1y What percent of Peruvian GDP is from ayahuasca-related tourism? No answer yet · Last followed 1y Are seagulls better at not ingesting plastic than albatrosses and other seabirds? No answer yet · Last followed 1y Does staying in a cave (without light) for more than 5 days cause the body to convert all the extra melatonin into endogenous DMT, causing hallucinations that may have spawned the Abrahamic religions? No answer yet · Last followed 1y What is the Straussian reading of Girard in an Orwellian world? No answer yet · Last followed 1y How much genetic diversity is there among amerindians relative to Europeans? No answer yet · Last followed 1y Why do Joscha Bach tangents have higher recursive depth than those of anyone? No answer yet · Last followed 1y How is Michigan hunting culture similar/different to Pennsylvania hunting culture? Is it affected by Michigan being much flatter? No answer yet · Last followed 1y Why aren't superforecasters the best sense-makers (like daniel schmachtenberger level of sense-making)? No answer yet · Last followed 1y Would a friendly artificial superintelligence be a Taoist ruler? No answer yet · Last followed 1y What antiemetics prevent vomiting on Ayahuasca? 1 answer · Last followed 1y Is "why greatness cannot be planned" (Ken Stanley) a Taoist text? No answer yet · Last followed 1y If someone uses the same phrase over and over again in a wide variety of contexts BEFORE it gets read by the transformer LLM, wll it substantially update the weights and logits of the transformer model? No answer yet · Last followed 1y Are functionalist theories of psychology held by mind-uploading advocates? No answer yet · Last followed 1y Why didn't Stephen Hsu become a faculty member at a top-50 research university (or even flagship state university)? No answer yet · Last followed 1y How do transformer models detect sarcasm? No answer yet · Last followed 1y Are e-bikes safer than regular bikes at low speeds/if you control for speed? 4 answers · Last followed 1y Did Lao Tzu drink loads of tea? No answer yet · Last followed 1y Are true Buddhists/Taoists often perceived as frequently ghosting people? 1 answer · Last followed 1y Why is unschooling so Taoist? No answer yet · Last followed 1y Why is ADHD so compatible with Taoism? 1 answer · Last followed 1y Do hard drives store better in low humidity? No answer yet · Last followed 1y Why does avast consider key automation software (like autotab and autohotkeys) to be suspicious files? No answer yet · Last followed 1y How well do diffusion transformers do out of distribution generalization (OOG)? No answer yet · Last followed 1y Do people with ADHD have different ratios (and variances) of phasic dopamine vs tonic dopamine than neurotypicals? No answer yet · Last followed 1y The distribution of the counts across all genes tends to follow a Poisson distribution (or a zero-inflated negative binomial distribution) => why? No answer yet · Last followed 1y Does methylating a CpG site increase mutation rate of the site of new generations? Does it depend on whether it is at a bivalent promoter/open sea/shore? No answer yet · Last followed 1y Do monosialyated IgG glycans reduce inflammation/inhibit complement pro-inflammatory complement protein synthesis more than disialyated glycans? No answer yet · Last followed 1y Do any of the open chromatin regions in ATAC-clock that change most with age correspond to splicesome regulating factors like SRSF1? No answer yet · Last followed 1y In epigenome-wide mendelian randomization, how do you select for similar genomic context/location and baseline methylation [for mediation] when control methylation marks are almost never the same (within a person across time AND between people)? No answer yet · Last followed 1y Is calorie restriction bad at reducing the stochastic component of epigenetic aging like HorvathAge (cf Tarkhov's paper)? No answer yet · Last followed 1y Why does loss of potassium channel signalling with age increase depolarization and noise in the cell? No answer yet · Last followed 1y How does one minimize scarring/fibrosis during organ replacement? No answer yet · Last followed 1y How does trauma increase glycanage in a cortisol-independent mechanism? No answer yet · Last followed 1y Does OSKM reprogramming produce effects on neurons/neuroplasticity similar to chemical histone deacetylase (HDAC) inhibitors? No answer yet · Last followed 1y Does extrinsic age acceleraton act primarily through changing the immune system composition (reducing naive lymphocytes and increasing neutrophil composition)? No answer yet · Last followed 1y Do M2F people who take estrogen (become transgender) reduce their glycanage in the process? 2 answers · Last followed 1y Does DauT have a slower epigenetic rate of aging than TheViper? Can we determine just by screen recordings alone? No answer yet · Last followed 1y Does estrogen increase hair follicle stem cell count/density? No answer yet · Last followed 1y Are "systemic aging" clocks more affected by how cell population composition of immune cells (eg NK cells) change with age - than "intrinsic aging" clocks? No answer yet · Last followed 1y Does Google NotebookLM appropriately capture data from supplementary figures if I submit a bioarxiv webpage or PDF of a paper? No answer yet · Last followed 1y Do I lose my Google NotebookLM output if I don't save my notes? No answer yet · Last followed 1y Isn’t average rate of change in methylation in bivalent promoter sites also related to average rate of change in methylation in PRC2 sites? No answer yet · Last followed 1y How do I remove images I uploaded to Quora? 1 answer · Last followed 1y If I upload an image to a comment/answer on Quora I later delete, will the image stay on Quora? 1 answer · Last followed 1y Why are LLM tokenizers unelegant? 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No answer yet · Last followed 1y Is brainmaster amplifier better than other amps (eg Deymed/Cadwell) in measuring ERPs/SCPs? No answer yet · Last followed 1y Why do so many human augmentation researchers come from Japan (eg https://plopes.org/ students), Yoky Matsuoka? No answer yet · Last followed 1y Are TKS'ers more prone to virtue-signalling than hackclubbers? No answer yet · Last followed 1y Does decomposition of neuroscience data via ICA often uncover Event-related potentials (ERP) as principle ICA components? No answer yet · Last followed 1y To what extent does Vitalik Buterin's autism explain why he has such high integrity? No answer yet · Last followed 1y Does freezing a bag of frozen vegetables increase/decrease the rate/megasecond at which microplastics leach into the vegetables? 2 answers · Last followed 1y Can macrophages go/live inside cells? 1 answer · Last followed 1y What is the average annual death rate of Axolotl? No answer yet · Last followed 1y Why do axolotl genomes gain methylation with age on average, in an anti-(matthew effect) matter? No answer yet · Last followed 1y Can transcranial focused ultrasound make psychedelics more controllable (and less like a waking dream)? No answer yet · Last followed 1y Does constantly dedifferentiating the body (epigenetically rejuvenating it) also compromise the immune system, particularly memory cells? 1 answer · Last followed 1y Why do anti-TNF drugs cause demyelination? No answer yet · Last followed 1y Does DNA damage lead to the hypermethylation of some CpG sites? No answer yet · Last followed 1y What are the issues with ElasticNet being overly used for methylation/epigenetic clocks? No answer yet · Last followed 1y What apps measure lag time based on screen recordings of Android/PC/iOS data? 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No answer yet · Last followed 1y How does compost type and fungi/bacterial ratio of soil affect nutritional value/B Vitamins absorbed by eating plants? No answer yet · Last followed 1y Are plant sterols more atherogenic than cholesterol, as Peter Attia says? Why or why not? No answer yet · Last followed 1y Does how unevenly matter is distributed in a universe affect its expansion rate? 1 answer · Last followed 1y Does shunting inhibition in neurons explain Weber's law, or the brain's (in) ability to encode differences in magnitude at equal precision at multiple scales? No answer yet · Last followed 1y Does shunting inhibition in neurons explain the Weber law? No answer yet · Last followed 1y How do neurons encode time elapsed (like difference between 5, 6, 7 or between 14 and 16 seconds)? Is it higher precision for smaller intervals of time? No answer yet · Last followed 1y Does grinded pepper have significant microplastic contamination from the pepper grinder? 1 answer · Last followed 1y Do birds have lower retrotransposon activity than mammals? 1 answer · Last followed 1y Why are oxidized retinoids less likely to form free radical/oxoaldehyde chain reactions or Michael adducts than oxidized lipids/proteins? No answer yet · Last followed 1y Why are oxidized xanthophyll carotenoids (like lutein) less likely to form free radical/oxoaldehyde chain reactions or Michael adducts than oxidized lipids/proteins? No answer yet · Last followed 1y Why is Omega 3 rich fish not unusually rich in vitamin E/tocotrienols/tocopherols? No answer yet · Last followed 1y Why are lipids more easily oxidized/damaged than proteins/carbohydrates/DNA bases? No answer yet · Last followed 1y Why are oxidized triterpenoids less likely to continue to free radical or oxoaldehyde chain reactions/Michael adducts than oxidized cholesterol or lipids? No answer yet · Last followed 1y Why are oxidized vitamin E/tocotrienols/tocopherols less likely to continue to free radical or oxoaldehyde chain reactions/Michael adducts than oxidized lipids or cholesterol? No answer yet · Last followed 1y Will parametric statistics lose market share to non-parametric statistics in the 2020s? No answer yet · Last followed 1y What animals have the lowest amount of retrotransposon activity? 1 answer · Last followed 1y Is retrotransposon activation with aging less severe in post-mitotic/non-dividing cells like neurons than mitotic cells which lose methylation marks with each division? No answer yet · Last followed 1y Are there more possible entangled qubit states than separable Qubit states? 1 answer · Last followed 1y If dark energy is not constant as we're discovering from the DESI instrument, is it possible for it to weaken just enough for the universe to end up at a steady size for infinity? 1 answer · Last followed 1y Is shot noise ever used in thermodynamic computing? No answer yet · Last followed 1y Is dS/dq (change in entropy) higher for the atmosphere than the oceans? No answer yet · Last followed 1y How is dS (change in entropy) per dQ for distributing heat into more vibrational energy states of a gas with high heat capacity different from doing by increasing the temperature of a gas with lower heat capacity whose dT/dQ increases more quickly? No answer yet · Last followed 1y Do greenhouse gases have higher heat capacity, and how does this affect sensitivity in climate models? 2 answers · Last followed 1y Do human tissue/blood/histology samples show more microplastic, air pollution, rock/dirt/sand, or insoluble biological fiber (eg wood microparticle) contamination? No answer yet · Last followed 1y Does Bing (like duckduckgo, perplexity.ai, and exa.ai) heavily penalize Quora answers in its answer rankings? No answer yet · Last followed 1y Can some compression file formats use mutual information in some files in the .rar/tar equivalent to compress other files? 2 answers · Last followed 1y How does neurosymbolic AI reduce technical debt compared with approaches like neural nets/transformers? (Cf Gary Marcus) No answer yet · Last followed 1y Does the fact that proteins are highly evolutionarily constrained in their structure make structure prediction way easier to do zero-shot and w/o precise understanding of their physics, esp by Evo [Arc Institute]? 1 answer · Last followed 2y Do athletes accumulate more microplastics in their tissue due to higher levels of calorie consumption/nutrient flux? No answer yet · Last followed 2y Is it true that after the DeepMind-Google Brain merger, that many DeepMind employees had to cancel "blue skies"/more exploratory research areas for more short-term LLM-related work? No answer yet · Last followed 2y Can Sam Altman/Dario Amodei/Demis Hassabis be counted on to consistently act on "good faith"? No answer yet · Last followed 2y How is epigenome-wide Mendelian Randomization (EWMR) different from Mendelian Randomization, esp. when epigenetic methylation values are not as binary as MR? No answer yet · Last followed 2y Is there a Markov blanket/boundary between Burning Man and the rest of the world? No answer yet · Last followed 2y Is replicability harder if intervention can give opposite effects (e.g., REBUS vs SEBUS) in some people making means more equal, even replicibility of variance-based t-tests? No answer yet · Last followed 2y As first order approximation, are replications more common/expected in cell lines/in vitro or in whole organisms/in vivo? In practice, does replication hacking happen more in one of these? No answer yet · Last followed 2y Are deuterated aldehydes less toxic/reactive? No answer yet · Last followed 2y Do hydrogen atoms from drinking water get incorporated into cell membranes/proteins/fats in the body at rates different than hydrogen atoms from food/other sources? No answer yet · Last followed 2y Are nodes outside of the Markov blanket d-separated from each other? No answer yet · Last followed 2y What pulse waveforms/widths/shapes/separation determine the difference between "activating" and "inhibiting" a region in Transcranial focused ultrasound (tFUS)? No answer yet · Last followed 2y Does aging cause a greater global decrease in N-glycosylation or in O-glycosylation? No answer yet · Last followed 2y Do acidic environments protect against oxidative stress caused to lysine/arginine residues? No answer yet · Last followed 2y Which (pre) synaptic proteins (eg PSD95, MAP2, synaptophysin, neuregulin, neurexin, complexin, integrins, talins) have radiotracers for them? Which ones don't? No answer yet · Last followed 2y What percent of grey/white matter come just from dendritic spines? No answer yet · Last followed 2y How do Yamanaka reprogramming factors address existing damage to the extracellular matrix, lipofuscin, or aggregated proteins? No answer yet · Last followed 2y How do you deliver Yamanaka reprogramming factors in a highly precise and controlled way to a tissue? No answer yet · Last followed 2y Is increased sialyation on IgG proteins correlated with increased sialyation on all other proteins? No answer yet · Last followed 2y In allogenic stem cell transplantation, how evenly are donor stem cells distributed across all of a recipient’s bone marrow? No answer yet · Last followed 2y Do a large percent of stem cells that go from bone marrow into blood go back into bone marrow the next day (at a different location of bone marrow)? No answer yet · Last followed 2y Is burnout a form of immaturity? 1 answer · Last followed 2y What is the spread (or ratio) of biological/epigenetic age clocks around the mortality rate doubling time in humans and animals? No answer yet · Last followed 2y Does the pre-existing concentration (of lack of) of stem cells in one part of bone marrow affect how many will migrate to (or out) of the same portion the next day? (eg CXCR4/selectin) No answer yet · Last followed 2y Is there a Moore's law for read or write speeds like MB/s? 1 answer · Last followed 2y Is it harder for new neurons to migrate into L4 excitatory neurons or inhibitory PV/SST interneurons? 1 answer · Last followed 2y How does calorie restriction affect cyclin D relative to other cyclins? No answer yet · Last followed 2y Does the relationship between testosterone level and delta (epigenetic age) /ageAccel change with age (b/c higher-testosterone at later ages is a sign of slowed aging, overcoming the pro-aging effects of testosterone)? No answer yet · Last followed 2y Why are visual neurons less affected by alzheimer's than other neurons [esp associative area ones]? No answer yet · Last followed 2y Can Twitter's grok search in someone's liked items? No answer yet · Last followed 2y What CpG sites correspond to bivalent promoters? No answer yet · Last followed 2y Do the benefits of TMS fall off with time if one stops TMS? No answer yet · Last followed 2y Can neuronal stem cells (esp in organoids) excrete exophers? No answer yet · Last followed 2y Is plasma NfL a measure of neuronal exophers in younger people? No answer yet · Last followed 2y How does the level of autism/asperger's compare between Anthropic, OpenAI, xAI, DeepMind, Scale AI, DataBricks/MosaicML, NVIDIA, Luminous Computing, Microsoft Research, Cerebras, Adept, and transformers mafia? No answer yet · Last followed 2y How common is it for people to complain about Quora employees (or Quora power users/celebrities) for behavior made outside of Quora directly to Adam d'Angelo? No answer yet · Last followed 2y Are Anthropic or OpenAI researchers smarter on raw cognitive capacity/bandwidth/operations per second? No answer yet · Last followed 2y What online forums did millennial AI researchers (eg Andrej Karpathy/Ilya Sutskever/Sam Altman/Alex Lamb/Greg Brockman/davidad/David Ha/George Hotz/Lilian Weng/Ian Goodfellow/Noam Shazeer/Aidan N. Gomez/Jim Fan/finbarr/etc) read as teenagers? No answer yet · Last followed 2y Do you have to hold your head still for the entire duration of transcranial magnetic stimulation? No answer yet · Last followed 2y Can TMS machines damage smartphones in the vicinity? (is it unsafe to use a smartphone